S1PR2
S1PR2 (sphingosine-1-phosphate receptor 2, also known as EDG5, H218, AGR16 and Gpcr13) is a G protein-coupled receptor for the bioactive lysophospholipid sphingosine 1-phosphate (S1P). It links S1P binding to cell proliferation, survival and growth control. Browse Assay Genie's current range of S1PR2 research reagents below, or read on for the biology behind the target.
S1PR2 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, it can mediate S1P-induced cell proliferation and suppression of apoptosis. The NCBI Gene summary describes S1P as participating in cell proliferation, survival and transcriptional activation.
S1PR2 also acts as a receptor for the chemokine-like protein FAM19A5, and mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration. In lymphoid follicles, it couples S1P binding to activation of GNA13 and downstream inhibition of AKT activation. This suppresses the growth of germinal centre (GC) B cells and their migration outside the GC niche.
The S1PR2 gene encodes a member of the G protein-coupled receptor 1 family and of the EDG family of proteins, and it sits in the HGNC group of sphingosine 1-phosphate receptors. The protein is found at the cell membrane. The gene was previously named endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 (EDG5). It also carries the earlier designation deafness, autosomal recessive 68 (DFNB68), because defects in the gene have been associated with congenital profound deafness. Mouse and rat both have an S1pr2 ortholog.
S1PR2 is a receptor for S1P, a bioactive lysophospholipid acting on most cell and tissue types, making it a focus for sphingolipid signalling studies.
In lymphoid follicles S1PR2 couples S1P to GNA13 and AKT inhibition, restraining GC B cell growth and migration beyond the GC niche.
S1PR2 mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration.
Defects in the S1PR2 gene have been associated with congenital profound deafness, linking the receptor to inherited hearing loss research.
S1PR2 is a cell membrane receptor for sphingosine 1-phosphate. It can mediate S1P-induced proliferation and suppression of apoptosis, and it also binds FAM19A5. In lymphoid follicles it signals through GNA13 to inhibit AKT activation and limit germinal centre B cell growth.
S1PR2 is also called EDG5, H218, AGR16 and Gpcr13. Its former HGNC name was endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, and the symbol DFNB68 refers to autosomal recessive deafness 68. It belongs to the sphingosine 1-phosphate receptor gene group.
Mouse and rat each have an S1pr2 ortholog, and rat HTC4 hepatoma cells have been used to show S1P-induced proliferation mediated by the receptor. Defects in the human gene have been associated with congenital profound deafness. Check the datasheet of any product for its validated reactivity.
Other sphingosine 1-phosphate receptors, G protein partners and signalling proteins linked to S1PR2 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95136; product specifications from Assay Genie datasheets.