RAB11B
RAB11B (Ras-related protein Rab-11B, also known as H-YPT3) is a small GTPase of the Rab family that regulates intracellular membrane trafficking. It has a particular role in endocytic recycling, the movement of transmembrane proteins back to the cell surface. Browse Assay Genie's current range of RAB11B research reagents below, or read on for the biology behind the target.
Rab proteins are key regulators of intracellular membrane trafficking, acting from the formation of transport vesicles through to their fusion with target membranes. Like other Rabs, RAB11B cycles between an inactive GDP-bound form and an active GTP-bound form. The active form recruits sets of downstream effectors that are directly responsible for vesicle formation, movement, tethering and fusion.
RAB11B plays a role in endocytic recycling and regulates the apical recycling of several transmembrane proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), a potassium voltage-gated channel and the voltage-dependent L-type calcium channel. It may also regulate constitutive and regulated secretion, such as insulin granule exocytosis, and is required for melanosome transport and release from melanocytes. It also regulates V-ATPase intracellular transport in response to extracellular acidosis.
RAB11B also contributes to ciliogenesis. It promotes preciliary vesicular trafficking of Rabin8/RAB3IP to the mother centriole by forming a ciliary targeting complex with ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which regulates initiation of ciliogenesis. When the LPAR1 receptor signalling pathway is activated, interaction with phosphorylated WDR44 prevents formation of the Rab11-RAB3IP-RAB11FIP3 complex and cilia growth. RAB11B also interacts with RABL3 to promote ciliary vesicle formation. The protein belongs to the Rab family of the small GTPase superfamily, and is found on recycling endosome, synaptic vesicle and phagosome membranes. The RAB11B gene is a member of the HGNC group of RAB, member RAS oncogene GTPases, with mouse and rat orthologs each named Rab11b.
RAB11B regulates the apical recycling of transmembrane proteins, making it a focus for studies of how receptors and channels return to the cell surface.
It is involved in the trafficking of CFTR, ENaC, potassium voltage-gated channels and L-type calcium channels, relevant to epithelial transport research.
RAB11B participates in a ciliary targeting complex that regulates initiation of ciliogenesis, and in ciliary vesicle formation with RABL3.
RAB11B may regulate insulin granule exocytosis and is required for melanosome transport and release from melanocytes.
RAB11B is a small GTPase that regulates intracellular membrane trafficking. It cycles between GDP-bound inactive and GTP-bound active states, recruiting effectors for vesicle formation, movement, tethering and fusion. It plays a role in endocytic recycling and in the initiation of ciliogenesis.
The HGNC name is RAB11B, member RAS oncogene family, and UniProt names the protein Ras-related protein Rab-11B. H-YPT3 is a listed alias. It belongs to the Rab family of the small GTPase superfamily and carries the enzyme classification EC 3.6.5.2.
Orthologs exist in mouse and rat, and both are named Rab11b. NCBI Gene describes the Rab family, including RAB11B, as playing a critical role in regulating exocytotic and endocytotic pathways. Check the datasheet of any product for its validated reactivity.
Other Rab GTPases, Rab11 effectors and trafficking regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15907; product specifications from Assay Genie datasheets.