SPON1
SPON1 (spondin 1, also known as f-spondin or KIAA0762) is a secreted extracellular matrix protein that acts as a cell adhesion factor. It promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. Browse Assay Genie's current range of SPON1 research reagents below, or read on for the biology behind the target.
SPON1 is a cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. It may contribute to the growth and guidance of axons in both the spinal cord and the peripheral nervous system. The UniProt annotation also describes it as a major factor for vascular smooth muscle cell, pointing to roles beyond the nervous system.
The human SPON1 gene encodes spondin-1, a secreted protein found in the extracellular space and extracellular matrix. NCBI Gene summarises it as a predicted extracellular matrix structural constituent involved in cell adhesion. Researchers looking for an SPON1 antibody, SPON1 ELISA kit or recombinant SPON1 protein typically work on neural development, matrix biology and related questions.
Genome annotation also predicts that SPON1 acts upstream of or within the negative regulation of amyloid-beta formation, the positive regulation of amyloid precursor protein catabolic process and the positive regulation of protein processing. These links are predicted rather than established, and they connect the protein to amyloid precursor protein handling.
The gene was previously named spondin 1, (f-spondin) extracellular matrix protein, and the alias f-spondin remains in common use. The SPON1 gene has mouse and rat orthologs, both named Spon1, which allows comparative work in rodent models. SPON2 is a related spondin gene.
SPON1 promotes neurite outgrowth and the attachment of spinal cord and sensory neurons in vitro, making it relevant to studies of neuronal adhesion.
SPON1 may contribute to the growth and guidance of axons in the spinal cord and the peripheral nervous system.
SPON1 is a secreted cell adhesion protein located in the extracellular matrix, predicted to act as a structural constituent.
SPON1 is predicted to act in the negative regulation of amyloid-beta formation and the positive regulation of amyloid precursor protein catabolism.
SPON1 is a secreted cell adhesion protein. It promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro, and it may contribute to axon growth and guidance in the spinal cord and peripheral nervous system.
SPON1 stands for spondin 1 and is also called f-spondin or KIAA0762. Its earlier HGNC name was spondin 1, (f-spondin) extracellular matrix protein. UniProt lists the protein as Spondin-1. Check aliases when searching the literature, as papers often use f-spondin.
Yes. Mouse and rat both carry a Spon1 ortholog, so rodent models can be used to study its function. Check the datasheet of any product for its validated reactivity before planning cross-species experiments.
A related spondin family member with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HCB6; product specifications from Assay Genie datasheets.