OR51E2
OR51E2 (olfactory receptor family 51 subfamily E member 2, also known as PSGR) is a G protein-coupled olfactory receptor activated by short-chain fatty acids and the odorant beta-ionone. Beyond smell, it has been linked to cell proliferation, melanogenesis and renin secretion. Browse Assay Genie's current range of OR51E2 research reagents below, or read on for the biology behind the target.
OR51E2 is an olfactory receptor activated by short-chain fatty acids (SCFA), such as acetate and propionate, and by beta-ionone, a synthetic terpenoid odorant. Ligand binding causes a conformational change that triggers signalling through the G(s)-class G alpha protein GNAL (G(olf)). This activates adenylate cyclase and increases production of cAMP, initiating a neuronal response that underlies the perception of a smell.
The OR51E2 protein belongs to the G protein-coupled receptor 1 family and sits in the HGNC group of olfactory receptors, family 51. Like other olfactory receptors, it shares the seven-transmembrane domain structure of many neurotransmitter and hormone receptors. Olfactory receptor genes arise from single coding exons and form the largest gene family in the genome. UniProt places OR51E2 at the cell membrane and the early endosome membrane. The gene was formerly named olfactory receptor, family 51, subfamily E, member 2, and carries the alias PSGR.
Functions outside olfaction are described as well. OR51E2 may be activated by steroid hormones and may regulate cell proliferation. Stimulation by beta-ionone affects melanocyte proliferation, differentiation and melanogenesis, and increases proliferation and migration of primary retinal pigment epithelial cells. In response to SCFA, it may positively regulate renin secretion and increase blood pressure, and it is activated by L-lactate in glomus cells. These roles make the OR51E2 gene a useful subject for studies of ectopic olfactory receptor signalling.
OR51E2 couples to GNAL (G(olf)) to activate adenylate cyclase and raise cAMP, providing a model for odorant-driven GPCR signalling.
Beta-ionone stimulation of OR51E2 affects melanocyte proliferation, differentiation and melanogenesis.
Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial cells.
In response to short-chain fatty acids, OR51E2 may positively regulate renin secretion and increase blood pressure.
OR51E2 is an olfactory receptor that responds to short-chain fatty acids such as acetate and propionate, and to beta-ionone. Activation signals through GNAL (G(olf)), stimulating adenylate cyclase and raising cAMP. It also appears to act outside the nose, affecting cell proliferation and renin secretion.
The HGNC name is olfactory receptor family 51 subfamily E member 2, and UniProt lists it as olfactory receptor 51E2. PSGR is a recorded alias. The earlier name was olfactory receptor, family 51, subfamily E, member 2. It belongs to the olfactory receptors, family 51 gene group.
Orthologues named Or51e2 exist in both mouse and rat. Human OR51E2 is linked to melanocyte, retinal pigment epithelial and renin-related responses to its ligands. Check the datasheet of any product for its validated reactivity.
Pathway partners and signalling targets related to OR51E2 research with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H255; product specifications from Assay Genie datasheets.