H1-0
H1-0 (H1.0 linker histone, also known as H1.0, H1FV and H1F0) is a linker histone that binds DNA between nucleosomes and helps compact chromatin into higher-order fibres. It is a member of the histone H1/H5 family and is found in cells with low division rates or in terminal differentiation. Browse Assay Genie's current range of H1-0 research reagents below, or read on for the biology behind the target.
H1-0 is a linker histone. Histone H1 proteins bind to the linker DNA between nucleosomes, forming the macromolecular structure known as the chromatin fibre. They are necessary for the condensation of nucleosome chains into higher-order structured fibres, and they promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The H1.0 histone is found in cells that are in the terminal stages of differentiation or that have low rates of cell division.
Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fibre in eukaryotes. A nucleosome consists of approximately 146 bp of DNA wrapped around an octamer of the four core histones (H2A, H2B, H3 and H4). The linker histone H1 then interacts with the DNA between nucleosomes, compacting the fibre into higher-order chromatin structures. The H1-0 gene is intronless and encodes a replication-independent histone, which sets it apart from replication-dependent histone genes. The H1-0 protein belongs to the histone H1/H5 family and localises to the nucleus, including the nucleolus, and to chromosomes. Mouse and rat orthologs are also named H1-0.
The gene is listed by HGNC in the H1 histones group. Earlier symbols include H1F0 and H1FV, and previous names include H1 histone family, member 0. Researchers working with H1-0 may therefore encounter these older designations in the literature when studying chromatin architecture, differentiation and epigenetic regulation.
H1-0 binds linker DNA between nucleosomes and is necessary for condensing nucleosome chains into higher-order chromatin fibres.
Histone H1 promotes formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, linking linker histones to repressive chromatin marks.
H1.0 is found in cells in terminal stages of differentiation, making it relevant to studies of differentiated cell states.
H1-0 is enriched in cells with low rates of cell division, and it is a replication-independent histone.
H1-0 binds linker DNA between nucleosomes and helps form the chromatin fibre. Histones H1 are necessary for condensing nucleosome chains into higher-order fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Check the datasheet of any product for its validated reactivity.
H1-0 is the current HGNC symbol for the H1.0 linker histone. It is also called H1.0, H1FV and H1F0, and UniProt names the protein histone H1.0. Older names include H1 histone family, member 0, so searches may use any of these.
UniProt reports that H1.0 is found in cells in terminal stages of differentiation or with low rates of cell division. The gene is intronless and encodes a replication-independent histone. Mouse and rat both have an ortholog named H1-0.
Other H1 linker histones, PRC2 components and core histone targets relevant to chromatin research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07305; product specifications from Assay Genie datasheets.