GCA
GCA (grancalcin, also known as GCL) is a calcium-binding protein that is abundant in neutrophils and macrophages. It may contribute to neutrophil adhesion to fibronectin and to the formation of focal adhesions. Browse Assay Genie's current range of GCA research reagents below, or read on for the biology behind the target.
GCA is a calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. It may also take part in the formation of focal adhesions. These functions place grancalcin in the cellular machinery that links calcium signalling to cell attachment, although the source annotation describes both roles as possible rather than established.
The GCA gene encodes a protein that is abundant in neutrophils and macrophages. Its localisation depends on the ionic environment. With no divalent cation present, the protein is found in the cytosolic fraction. With magnesium alone, it partitions with the granule fraction. With both magnesium and calcium, it associates with the granule and membrane fractions. This behaviour is consistent with the UniProt subcellular annotation of cytoplasm and cytoplasmic granule membrane. Alternative splicing and the use of alternative promoters give rise to multiple transcript variants of the GCA gene.
HGNC classifies grancalcin in the EF-hand domain containing gene group. Earlier names include grancalcin, EF-hand calcium-binding protein, and the previous symbol GCL. The mouse ortholog is Gca. Researchers studying neutrophil and macrophage biology, calcium-dependent protein behaviour or cell adhesion may use GCA as a target when designing an experiment, whether they work with a GCA antibody, a GCA ELISA kit or recombinant GCA protein.
GCA may play a role in the adhesion of neutrophils to fibronectin, making it a candidate for studies of neutrophil attachment.
GCA may contribute to the formation of focal adhesions, which links this calcium-binding protein to cell–matrix contact research.
Grancalcin shifts between cytosolic, granule and membrane fractions depending on magnesium and calcium, which makes it a model for ion-regulated partitioning.
GCA is abundant in neutrophils and macrophages, so it is relevant to studies of these myeloid cell types.
GCA is a calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin and in the formation of focal adhesions. It is abundant in neutrophils and macrophages, and its association with granule and membrane fractions depends on magnesium and calcium.
GCA is also known as GCL, and HGNC lists earlier names such as grancalcin, EF-hand calcium-binding protein. The gene produces multiple transcript variants through alternative splicing and the use of alternative promoters.
Yes, the mouse ortholog is named Gca. The rat ortholog is not given in the data supplied here. Researchers working across species should check the datasheet of any product for its validated reactivity.
Other EF-hand calcium-binding proteins, adhesion molecules and myeloid cell markers that may be relevant to grancalcin research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P28676; product specifications from Assay Genie datasheets.