THRB
THRB (thyroid hormone receptor beta, also known as NR1A2, THRB1, THRB2, TRbeta and ERBA-BETA) is a nuclear hormone receptor that binds thyroid hormones with high affinity. It can act as either a repressor or an activator of transcription. Browse Assay Genie's current range of THRB research reagents below, or read on for the biology behind the target.
THRB is a nuclear hormone receptor that can function as a repressor or an activator of transcription. It is a high-affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. The NCBI Gene summary describes it as a receptor for triiodothyronine that mediates the biological activities of thyroid hormone. The THRB protein localises to the nucleus, consistent with its role in regulating gene transcription.
THRB is one of several thyroid hormone receptors. It belongs to the nuclear hormone receptor family, NR1 subfamily, and the HGNC places the THRB gene in the group of thyroid hormone receptors. Knockout studies in mice suggest that the different thyroid hormone receptors have a degree of redundancy but may mediate different functions of thyroid hormone. Orthologues are annotated in mouse and rat, both named Thrb. Several alternatively spliced transcript variants of the gene have been observed, and all encode the same protein.
Mutations in the THRB gene are a known cause of generalised thyroid hormone resistance (GTHR). This syndrome is characterised by goitre and high levels of circulating thyroid hormones (T3 and T4), with normal or slightly elevated thyroid stimulating hormone (TSH). The gene's previous names reflect its history: it was first described as a homologue of the avian erythroblastic leukaemia viral oncogene v-erb-a, and as the locus for pituitary resistance to thyroid hormone. Alternative designations include c-erbA-beta, ERBA2, THR1, GRTH and PRTH.
THRB mediates the biological activities of thyroid hormone as a high-affinity receptor for triiodothyronine and thyroxine.
As a nuclear receptor that can repress or activate transcription, THRB is a model for hormone-dependent gene control.
Mutations in THRB cause generalised thyroid hormone resistance, marked by goitre and raised T3 and T4 with normal or slightly raised TSH.
Mouse knockout studies suggest thyroid hormone receptors show partial redundancy yet mediate distinct functions, making THRB relevant to subtype comparisons.
THRB is a nuclear hormone receptor that binds thyroid hormones, including triiodothyronine and thyroxine, with high affinity. It can act as a repressor or an activator of transcription and mediates the biological activities of thyroid hormone in the nucleus.
THRB is also called NR1A2, THRB1, THRB2, THR1, ERBA-BETA, ERBA2, GRTH, PRTH, TRbeta, TRb, c-erbA-beta and c-erbA-2. Several splice variants have been reported, and they all encode the same protein. Check the datasheet of any product for its validated reactivity.
Yes. Mutations in the THRB gene are a known cause of generalised thyroid hormone resistance. The syndrome features goitre and high circulating T3 and T4, with normal or slightly elevated TSH. Mouse and rat both carry a Thrb orthologue.
Other thyroid hormone receptors, nuclear receptor family members and thyroid signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10828; product specifications from Assay Genie datasheets.