IL13RA1
IL13RA1 (interleukin 13 receptor subunit alpha 1) is a membrane subunit of the interleukin-13 receptor and a primary IL-13-binding chain. It is also known as IL-13Ra, NR4 and CD213a1, and belongs to the type I cytokine receptor family. Browse Assay Genie's current range of IL13RA1 research reagents below, or read on for the biology behind the target.
IL13RA1 binds interleukin-13 (IL-13) with low affinity on its own. Together with IL-4 receptor alpha (IL4RA) it forms a functional receptor for IL-13, and it is described as the primary IL-13-binding subunit of that receptor complex. The IL4RA chain is shared by the IL-13 and IL-4 receptors, which is why the two cytokines overlap in the signals they trigger.
IL13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain (IL2RG) for interleukin-4 (IL-4) signalling. It cannot, however, replace IL2RG in enhancing interleukin-2 (IL-2) binding, so its role is specific to the IL-4 and IL-13 axis. The protein has been shown to bind the tyrosine kinase TYK2, and so may mediate the signalling that leads to activation of JAK1, STAT3 and STAT6 in response to IL-13 and IL-4.
The IL13RA1 gene encodes a membrane protein of the type I cytokine receptor family, type 5 subfamily. HGNC classes it among CD molecules and interleukin receptors, which accounts for the alias CD213a1. Earlier names include interleukin 13 receptor, alpha 1, and the aliases IL-13Ra and NR4. A mouse ortholog, Il13ra1, is recorded. Researchers studying IL-13 and IL-4 receptor assembly, JAK-STAT signalling and receptor subunit usage commonly work with IL13RA1 as an IL13RA1 antibody or IL13RA1 protein target.
IL13RA1 is the primary IL-13-binding subunit, so it is central to studies of how IL-13 engages its receptor complex with IL4RA.
IL13RA1 binds TYK2 and may mediate activation of JAK1, STAT3 and STAT6 downstream of IL-13 and IL-4.
IL13RA1 acts as an alternate accessory chain to IL2RG for IL-4 signalling, making it relevant to type II receptor complex research.
As a type I cytokine receptor family member in the type 5 subfamily, IL13RA1 is useful for comparative receptor studies.
IL13RA1 binds IL-13 with low affinity and, together with IL4RA, forms a functional IL-13 receptor. It can also act as an alternate accessory chain to IL2RG for IL-4 signalling. It binds TYK2 and may mediate JAK1, STAT3 and STAT6 activation.
The HGNC name is interleukin 13 receptor subunit alpha 1, with the previous name interleukin 13 receptor, alpha 1. Aliases include IL-13Ra, NR4 and CD213a1. UniProt lists the protein as interleukin-13 receptor subunit alpha-1.
A mouse ortholog, Il13ra1, is recorded for the human gene. No rat ortholog is given in the data available here. Check the datasheet of any product for its validated reactivity.
Other interleukins and cytokine signalling targets, including the IL-13 ligand, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78552; product specifications from Assay Genie datasheets.