COLEC12
COLEC12 (collectin subfamily member 12, also known as SRCL, CL-P1 and SCARA4) is a membrane scavenger receptor of the collectin family. It contributes to host defence by recognising microorganisms and by taking up oxidatively modified low density lipoprotein. Browse Assay Genie's current range of COLEC12 research reagents below, or read on for the biology behind the target.
COLEC12 is a scavenger receptor that displays several functions associated with host defence. It promotes the binding and phagocytosis of Gram-positive and Gram-negative bacteria and of yeast, and it can bind carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalisation and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.
The protein binds a range of carbohydrates in a calcium-dependent manner, including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, and the T and Tn antigens. It internalises GalNAc specifically in nurse-like cells, and it also binds sialyl Lewis X or a trisaccharide, and asialo-orosomucoid (ASOR). Its sugar-binding activity reflects its membership of the C-type lectin family, whose members combine collagen-like sequences with carbohydrate recognition domains.
The COLEC12 gene encodes Collectin-12, which is classed by HGNC in the collectins, scavenger receptors and C-type lectin domain containing groups. It is also known as SRCL, CL-P1 and SCARA4, names that reflect both its collectin and scavenger receptor character. UniProt notes that it may also play a role in the clearance of amyloid-beta in Alzheimer disease. Mouse and rat orthologs, both named Colec12, are recorded for comparative work.
COLEC12 promotes binding and phagocytosis of bacteria and yeast, making it a useful target for studying microbial recognition and clearance.
The receptor mediates recognition, internalisation and degradation of oxLDL by vascular endothelial cells, relevant to studies of modified lipoprotein handling.
COLEC12 binds Gal-type ligands, fucose, GalNAc, T and Tn antigens in a calcium-dependent manner, supporting work on carbohydrate recognition.
UniProt reports that COLEC12 may play a role in the clearance of amyloid-beta in Alzheimer disease.
COLEC12 is a scavenger receptor involved in host defence. It promotes binding and phagocytosis of bacteria and yeast, and it mediates recognition, internalisation and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. It also binds several carbohydrates in a calcium-dependent manner.
COLEC12 is the HGNC symbol for collectin subfamily member 12. The protein is called Collectin-12 in UniProt, and SRCL, CL-P1 and SCARA4 are used as aliases. The SCARA4 name reflects its classification among the scavenger receptors.
Yes. Mouse and rat orthologs, both named Colec12, are recorded for this gene, so rodent models can be used to study its function. Check the datasheet of any product for its validated reactivity.
["Other collectin family members and related C-type lectin targets with products at Assay Genie."][0]
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5KU26; product specifications from Assay Genie datasheets.