PITX1
PITX1 (paired like homeodomain 1, also known as pituitary homeobox 1, PTX1, POTX or BFT) is a sequence-specific transcription factor that binds gene promoters and activates their transcription. It belongs to the bicoid subfamily of paired homeobox proteins. Browse Assay Genie's current range of PITX1 research reagents below, or read on for the biology behind the target.
PITX1 is a sequence-specific transcription factor. It binds gene promoters and activates their transcription, and it is found in the nucleus. According to UniProt, it may play a role in the development of anterior structures, in particular the brain and facies, and in specifying the identity or structure of the hindlimb. The NCBI Gene summary also describes it as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
The PITX1 gene encodes a member of the RIEG/PITX homeobox family, which belongs to the bicoid class of homeodomain proteins. UniProt places the protein in the paired homeobox family, bicoid subfamily, and HGNC classifies the gene within the PRD class homeoboxes and pseudogenes. Members of the RIEG/PITX family are involved in organ development and left-right asymmetry. Related family members with pages at Assay Genie include PITX2 and PITX3.
The name pituitary homeobox 1 is the UniProt protein name. HGNC lists the approved name as paired like homeodomain 1, with previous names paired-like homeodomain transcription factor 1 and paired-like homeodomain 1. Earlier symbols include PTX1, POTX and BFT. Mouse and rat both have an orthologous Pitx1 gene, so researchers can study PITX1 biology in common rodent models.
PITX1 may contribute to the development of anterior structures, including the brain and facies, making it a subject of study in embryonic patterning.
UniProt notes a possible role for PITX1 in specifying the identity or structure of the hindlimb, relevant to limb development studies.
As a sequence-specific transcription factor that activates promoters, PITX1 is used to investigate homeodomain-driven gene control.
PITX1 acts as a transcriptional regulator in basal and hormone-regulated prolactin activity, linking it to pituitary and endocrine research.
PITX1 is a sequence-specific transcription factor that binds gene promoters and activates their transcription. It may play a role in the development of anterior structures such as the brain and facies, and in hindlimb identity. It also regulates basal and hormone-regulated prolactin activity.
PITX1 is also called pituitary homeobox 1 (the UniProt name), and has the aliases PTX1, POTX and BFT. HGNC lists previous names as paired-like homeodomain transcription factor 1 and paired-like homeodomain 1. The approved full name is paired like homeodomain 1.
Mouse and rat each have an orthologous Pitx1 gene. PITX1 belongs to the RIEG/PITX homeobox family of bicoid-class homeodomain proteins, which are involved in organ development and left-right asymmetry. Check the datasheet of any product for its validated reactivity.
Other PITX family homeodomain transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78337; product specifications from Assay Genie datasheets.