MPZL1
MPZL1 (myelin protein zero like 1, also known as PZR) is a cell surface receptor of the myelin P0 protein family that takes part in signal transduction. It recruits the phosphatase PTPN11/SHP-2 to the cell membrane and is a putative substrate of that enzyme. Browse Assay Genie's current range of MPZL1 research reagents below, or read on for the biology behind the target.
MPZL1 is a cell surface receptor involved in signal transduction. Its best-described activity is the recruitment of PTPN11/SHP-2 to the cell membrane, and it is also a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and contributes to the cellular signalling that ConA induces, which probably involves Src family tyrosine-protein kinases. Researchers studying tyrosine phosphorylation therefore often use MPZL1 as a model for receptor-phosphatase coupling.
The protein is found at the plasma membrane. NCBI Gene annotation describes it as enabling identical protein binding and as predicted to take part in cell surface receptor protein tyrosine kinase signalling, cell-cell signalling and the positive regulation of cell migration. UniProt notes that isoform 1, but not isoform 2 or isoform 3, may be involved in regulating integrin-mediated cell motility. Isoform 3 appears to act in a dominant negative manner, because it blocks the ConA-induced tyrosine phosphorylation of MPZL1.
The MPZL1 gene belongs to the V-set domain containing group in HGNC, and the protein belongs to the myelin P0 protein family. PZR and FLJ21047 are aliases for the same gene. Orthologues are annotated in mouse and rat as Mpzl1, which allows the receptor to be studied in common model systems. Any MPZL1 antibody, MPZL1 ELISA kit or MPZL1 protein reagent should be matched to the isoform and species relevant to your experiment.
MPZL1 recruits PTPN11/SHP-2 to the membrane and is a putative substrate of it, making it relevant to phosphatase-linked receptor signalling.
Isoform 1 may regulate integrin-mediated cell motility, and the gene is predicted to act in positive regulation of cell migration.
MPZL1 is a major receptor for concanavalin-A and mediates ConA-induced signalling that probably involves Src family kinases.
Isoform 3 appears dominant negative, blocking ConA-induced tyrosine phosphorylation of MPZL1, which allows comparison of isoform roles.
MPZL1 is a cell surface receptor involved in signal transduction. It recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of that phosphatase. It is also a major receptor for concanavalin-A, and isoform 1 may contribute to integrin-mediated cell motility.
MPZL1 is also called PZR, and FLJ21047 is another alias. The UniProt protein name is myelin protein zero-like protein 1. UniProt describes at least three isoforms: isoform 3 seems to be dominant negative, and only isoform 1 may regulate integrin-mediated motility.
Yes. Mouse and rat both have an orthologous gene named Mpzl1. The human protein belongs to the myelin P0 protein family. As with any target, check the datasheet of any product for its validated reactivity.
Partner phosphatases, Src family kinases and myelin P0 family members related to MPZL1 signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95297; product specifications from Assay Genie datasheets.