STK11
STK11 (serine/threonine kinase 11, also known as LKB1 and PJS) is a serine/threonine protein kinase that regulates cell polarity and energy metabolism and functions as a tumour suppressor. Mutations in the STK11 gene are associated with Peutz-Jeghers syndrome. Browse Assay Genie's current range of STK11 research reagents below, or read on for the biology behind the target.
STK11 is a serine/threonine kinase, classified under EC 2.7.11.1, that regulates cell polarity and energy metabolism and acts as a tumour suppressor. UniProt also annotates a role for the protein in spermiogenesis. Researchers studying growth control, metabolic signalling and epithelial organisation therefore work with STK11 as a point where these processes meet, whether they use an STK11 antibody, an STK11 ELISA kit or recombinant STK11 protein.
The protein belongs to the protein kinase superfamily, within the CAMK Ser/Thr protein kinase family and the LKB1 subfamily. HGNC places the gene in the STK11 family kinases group. Subcellular locations reported in UniProt include the nucleus, cytoplasm, membrane, mitochondrion and late endosome, which fits a kinase that acts in more than one cellular compartment. The human STK11 gene has orthologues named Stk11 in both mouse and rat, allowing comparative work in rodent models.
STK11 is best known through disease. Mutations in the gene are associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic and testicular cancers. This link explains the aliases and the earlier HGNC name, serine/threonine kinase 11 (Peutz-Jeghers syndrome), from which the PJS symbol derives. The alias LKB1 is also widely used in the literature, so both STK11 and LKB1 are worth searching when reviewing the field.
STK11 functions as a tumour suppressor, and its mutations are associated with skin, pancreatic and testicular cancers.
STK11 regulates cell polarity, making it a relevant target for work on how cells establish and maintain organisation.
The kinase regulates energy metabolism, so it is studied in research on how cells respond to metabolic state.
Mutations in STK11 are associated with autosomal dominant Peutz-Jeghers syndrome, which drives inherited disease research.
STK11 is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumour suppressor. UniProt additionally annotates a role in spermiogenesis. It belongs to the CAMK Ser/Thr protein kinase family, LKB1 subfamily.
LKB1 and PJS are recorded aliases of the gene. PJS refers to Peutz-Jeghers syndrome, which is linked to STK11 mutations and appeared in the earlier HGNC name, serine/threonine kinase 11 (Peutz-Jeghers syndrome). LKB1 is the alternative protein name used widely.
Yes. The mouse and rat orthologues are both named Stk11, so rodent models can be used to study the kinase. For cross-species work, check the datasheet of any product for its validated reactivity.
Other serine/threonine kinases in the STK family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15831; product specifications from Assay Genie datasheets.