CTRB1
CTRB1 (chymotrypsinogen B1, also known as CTRB) is a serine protease precursor and a principal precursor of the pancreatic proteolytic enzymes. It is secreted into the small intestine, where proteolytic activation generates the functional enzyme. Browse Assay Genie's current range of CTRB1 research reagents below, or read on for the biology behind the target.
CTRB1 encodes a member of the serine protease family and belongs to the peptidase S1 family. It forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesised in the acinar cells of the pancreas and secreted into the small intestine, where it undergoes proteolytic activation to generate a functional enzyme. The mature enzyme is classified under EC 3.4.21.1 and, in the extracellular space, acts as a chymotrypsin.
The CTRB1 gene is assigned by HGNC to the chymotrypsins and elastases gene group. It is located head-to-head with the related CTRB2 gene, and the gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. Mouse and rat both carry a Ctrb1 ortholog, which allows the biology of this chymotrypsinogen to be studied in common rodent models. The protein is also listed as chymotrypsinogen B, and the symbol CTRB is a previous alias for the gene.
CTRB1 is of particular interest in pancreatic disease genetics. Some human populations carry an alternate haplotype that inverts a 16.6 kb region containing portions of intron 1, exon 1 and the upstream sequence of CTRB1 and CTRB2, so that exon 1 and flanking sequence are swapped between the two genes. This inversion is associated with differential gene expression and with increased risk of chronic pancreatitis. The SNP rs8048956 in intron 1 of CTRB2 is diagnostic for the inversion, and the GRCh38 assembly represents its minor allele.
CTRB1 is a principal precursor of pancreatic proteolytic enzymes, made in acinar cells and activated in the small intestine.
A CTRB1/CTRB2 inversion haplotype is associated with differential gene expression and increased risk of chronic pancreatitis.
As a preproprotein that undergoes proteolytic activation, CTRB1 is a model for zymogen processing in the peptidase S1 family.
The head-to-head arrangement with CTRB2 and the presence of distinct isoforms make CTRB1 relevant to gene structure and variant analysis.
CTRB1 encodes chymotrypsinogen B1, a serine protease precursor and a principal precursor of the pancreatic proteolytic enzymes. It is synthesised in pancreatic acinar cells and secreted into the small intestine, where proteolytic activation generates the functional enzyme.
CTRB1 is the HGNC symbol for chymotrypsinogen B1, and the protein is also called chymotrypsinogen B. CTRB is a previous alias for the gene. The CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to produce the mature protein.
An inversion haplotype affecting CTRB1 and neighbouring CTRB2 is associated with differential gene expression and increased risk of chronic pancreatitis. Mouse and rat both have a Ctrb1 ortholog; check the datasheet of any product for its validated reactivity.
CTRB2, the head-to-head neighbouring gene, and other pancreatic serine proteases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P17538; product specifications from Assay Genie datasheets.