TMSB4X
TMSB4X (thymosin beta 4 X-linked, also known as TB4X or TMSB4) encodes thymosin beta-4, a small actin-sequestering protein of the thymosin beta family. It regulates actin polymerisation and contributes to cell proliferation, migration and differentiation. Browse Assay Genie's current range of TMSB4X research reagents below, or read on for the biology behind the target.
Thymosin beta-4 is an actin-sequestering protein. By binding actin and holding it in a form that is not incorporated into filaments, it plays a role in the regulation of actin polymerisation, a process central to cytoskeletal organisation. NCBI Gene also links the protein to cell proliferation, migration and differentiation. The UniProt annotation describes it as a potent inhibitor of bone marrow-derived stem cell differentiation, acting by inhibiting the entry of haematopoietic pluripotent stem cells into S-phase.
The TMSB4X gene encodes a very small protein that is found in the cytoplasm and is associated with the cytoskeleton. It belongs to the thymosin beta family, which also includes TMSB10. The TMSB4X gene is notable because it escapes X inactivation and has a homologue on the Y chromosome, so it is not silenced on the inactive X in females. Researchers working with the TMSB4X protein often study it alongside other actin regulators when investigating cytoskeletal dynamics and cell movement.
The approved HGNC name is thymosin beta 4 X-linked, and the gene was previously named thymosin, beta 4, X chromosome. Earlier symbols include TB4X and TMSB4. Orthologues are annotated in mouse and rat, both as Tmsb4x, which allows the gene to be studied in common rodent models. Interest in thymosin beta-4 spans cell biology, stem cell research and studies of proliferation and differentiation.
TMSB4X encodes an actin-sequestering protein that regulates actin polymerisation, making it a reference point for studies of cytoskeletal organisation.
Thymosin beta-4 is involved in cell migration, so it is relevant to work on how cells move and remodel their cytoskeleton.
UniProt describes thymosin beta-4 as a potent inhibitor of bone marrow-derived stem cell differentiation, relevant to haematopoietic stem cell research.
The protein is involved in cell proliferation and restricts haematopoietic pluripotent stem cells from entering S-phase, linking it to cell cycle studies.
TMSB4X encodes thymosin beta-4, an actin-sequestering protein that helps regulate actin polymerisation. It is also involved in cell proliferation, migration and differentiation. UniProt notes that it inhibits bone marrow-derived stem cell differentiation by blocking entry of haematopoietic pluripotent stem cells into S-phase.
The HGNC name is thymosin beta 4 X-linked, and the UniProt protein name is thymosin beta-4. Aliases and previous symbols include TB4X and TMSB4. The gene was previously called thymosin, beta 4, X chromosome. All of these refer to the same gene.
Mouse and rat both carry an orthologue named Tmsb4x. NCBI Gene reports that human TMSB4X escapes X inactivation and has a homologue on chromosome Y. Check the datasheet of any product for its validated reactivity.
Other thymosin beta family members and related cytoskeletal regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P62328; product specifications from Assay Genie datasheets.