ANGPTL5
ANGPTL5 (angiopoietin like 5, previously angiopoietin-like 5) is a secreted member of the angiopoietin-like family and carries a fibrinogen C domain. The UniProt entry names the protein angiopoietin-related protein 5. Browse Assay Genie's current range of ANGPTL5 research reagents below, or read on for the biology behind the target.
ANGPTL5 is a secreted protein. The UniProt record lists its subcellular location as secreted, and the NCBI Gene summary, which is based on prediction, places it in the extracellular region and describes it as active in the extracellular matrix. No detailed functional annotation or mechanism is currently curated for this protein, so its precise biological role is still to be established experimentally.
The ANGPTL5 gene encodes a protein of 388 amino acids. HGNC classifies it in two groups: the fibrinogen C domain containing genes and the angiopoietin like family. Members of this family share sequence relationships with the angiopoietins, which gives the group its name. Within the family, ANGPTL5 sits alongside ANGPTL1, ANGPTL2, ANGPTL6 and ANGPTL7, which are useful comparators when studying how the angiopoietin-like proteins differ.
The approved HGNC name is angiopoietin like 5, and the previous name was angiopoietin-like 5. UniProt uses the recommended name angiopoietin-related protein 5. Because the available annotation is limited, researchers working with the ANGPTL5 protein generally rely on the predicted extracellular localisation and its family relationships as the starting point for experimental design.
ANGPTL5 belongs to the angiopoietin like family, making it a point of comparison when studying how family members differ.
The gene is predicted to be active in the extracellular matrix, which makes it relevant to studies of matrix-associated secreted proteins.
UniProt records ANGPTL5 as secreted, so it is a candidate for work on extracellular protein release and distribution.
HGNC groups ANGPTL5 with fibrinogen C domain containing genes, supporting comparative work on this protein domain class.
The function of ANGPTL5 is not described in the UniProt annotation supplied here. The NCBI Gene summary predicts that it is located in the extracellular region and is active in the extracellular matrix. UniProt lists it as secreted, so it is considered an extracellular protein.
The HGNC approved name is angiopoietin like 5, and the previous name was angiopoietin-like 5. UniProt calls the protein angiopoietin-related protein 5. No alternative gene symbols are recorded, so the symbol ANGPTL5 is used consistently across these databases.
HGNC places ANGPTL5 in the angiopoietin like family and in the fibrinogen C domain containing group. Related family members with their own pages include ANGPTL1, ANGPTL2, ANGPTL6 and ANGPTL7. Check the datasheet of any product for its validated reactivity.
Other angiopoietin-like family members that share the fibrinogen C domain and extracellular localisation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86XS5; product specifications from Assay Genie datasheets.