SAMD9
SAMD9 (sterile alpha motif domain containing 9) is a cytoplasmic double-stranded nucleic acid-binding protein that acts as an antiviral factor. It is also known as KIAA2004, FLJ20073 and C7orf5, and has been linked to inflammatory responses and to normophosphatemic familial tumoral calcinosis. Browse Assay Genie's current range of SAMD9 research reagents below, or read on for the biology behind the target.
SAMD9 binds double-stranded nucleic acid and acts as an antiviral factor. According to UniProt, it plays an essential role in the formation of cytoplasmic antiviral granules. The protein is also proposed to contribute to the inflammatory response to tissue injury and to the control of extra-osseous calcification, acting as a downstream target of TNF signalling.
Beyond these roles, SAMD9 is involved in the regulation of EGR1, in coordination with RGL2, and may be involved in endosome fusion. The NCBI Gene summary adds that the encoded protein localises to the cytoplasm and may help regulate cell proliferation and apoptosis. This range of annotated activities makes the SAMD9 protein a point of contact between innate antiviral defence, cell growth control and tissue homeostasis.
The SAMD9 gene belongs to the HGNC group of sterile alpha motif domain containing genes. Its earlier name was chromosome 7 open reading frame 5 (C7orf5), and it has also been recorded as KIAA2004 and FLJ20073. Mutations in the gene cause normophosphatemic familial tumoral calcinosis. Alternate splicing gives multiple transcript variants, all of which encode the same protein. Researchers studying SAMD9 therefore work across virology, inflammation and calcification biology, often alongside other SAM domain proteins.
SAMD9 is essential for the formation of cytoplasmic antiviral granules, making it a focus for studies of how cells restrict viral infection.
SAMD9 may contribute to the inflammatory response to tissue injury and acts as a downstream target of TNF signalling.
Mutations in SAMD9 cause normophosphatemic familial tumoral calcinosis, and the protein may control extra-osseous calcification.
SAMD9 may regulate cell proliferation and apoptosis, and it participates in the regulation of EGR1 together with RGL2.
SAMD9 binds double-stranded nucleic acid and acts as an antiviral factor, playing an essential role in forming cytoplasmic antiviral granules. It may also contribute to the inflammatory response to tissue injury, regulate EGR1 with RGL2, and take part in endosome fusion.
SAMD9 is the HGNC symbol for sterile alpha motif domain containing 9. Aliases and previous symbols include KIAA2004, FLJ20073 and C7orf5, the last from the earlier name chromosome 7 open reading frame 5. Alternate splicing yields transcript variants that encode the same protein.
Yes. According to the NCBI Gene summary, mutations in SAMD9 cause normophosphatemic familial tumoral calcinosis. UniProt also notes a possible role in controlling extra-osseous calcification. Check the datasheet of any product for its validated reactivity before planning cross-species work.
Other sterile alpha motif domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5K651; product specifications from Assay Genie datasheets.