NAT8L
NAT8L (aspartate N-acetyltransferase, also known as N-acetylaspartate synthetase, Shati, Hcml3 and FLJ37478) is a membrane-associated enzyme that catalyses the synthesis of N-acetylaspartate (NAA) from L-aspartate and acetyl-CoA. It is a member of the NAT8 family of GCN5-related N-acetyltransferases. Browse Assay Genie's current range of NAT8L research reagents below, or read on for the biology behind the target.
NAT8L is an N-acetyltransferase that catalyses the synthesis of N-acetylaspartate (NAA) from L-aspartate and acetyl-CoA. The reaction is assigned EC 2.3.1.17. Beyond this core metabolic activity, UniProt annotation records that NAT8L promotes dopamine uptake by regulating TNF expression, and that it attenuates the methamphetamine-induced inhibition of dopamine uptake. Researchers searching for a NAT8L antibody, NAT8L ELISA kit or recombinant NAT8L protein are often studying one of these two roles: NAA metabolism or dopamine signalling.
The NAT8L gene encodes a membrane-associated enzyme. UniProt lists its subcellular locations as the cytoplasm, microsomal membrane, mitochondrial membrane and endoplasmic reticulum membrane. NAA is abundant in the nervous system, where it acts as a key metabolite with roles in metabolism and myelination. Outside the nervous system, the NAT8L gene is highly expressed in adipocytes, where it has been implicated in lipid synthesis and turnover. The protein belongs to the NAT8 family.
The official HGNC symbol is ASPNAT, and the gene belongs to the GCN5 related N-acetyltransferases group. Earlier names include N-acetyltransferase 8 like and N-acetyltransferase 8-like (GCN5-related, putative), and further aliases include Shati, Hcml3 and FLJ37478. Mutations in the gene may be associated with N-acetylaspartate deficiency, which makes NAT8L a point of interest for work on NAA biology and neurological metabolism.
NAT8L makes NAA, a key metabolite abundant in the nervous system that plays a role in metabolism and myelination.
NAT8L promotes dopamine uptake by regulating TNF expression and attenuates methamphetamine-induced inhibition of dopamine uptake.
Outside the nervous system, NAT8L is highly expressed in adipocytes, where it has been implicated in lipid synthesis and turnover.
Mutations in the NAT8L gene may be associated with N-acetylaspartate deficiency, making it relevant to inherited metabolic disorder research.
NAT8L is an N-acetyltransferase that catalyses the synthesis of N-acetylaspartate (NAA) from L-aspartate and acetyl-CoA. UniProt also reports that it promotes dopamine uptake by regulating TNF expression and attenuates methamphetamine-induced inhibition of dopamine uptake.
The HGNC symbol is ASPNAT, with the approved name aspartate N-acetyltransferase. UniProt calls it N-acetylaspartate synthetase. Aliases include Shati, Hcml3 and FLJ37478, and earlier names were N-acetyltransferase 8 like and N-acetyltransferase 8-like (GCN5-related, putative).
NAA is abundant in the nervous system, and NAT8L is also highly expressed in adipocytes, where it has been implicated in lipid synthesis and turnover. Mutations in the gene may be associated with N-acetylaspartate deficiency. Check the datasheet of any product for its validated reactivity.
Other N-acetyltransferases, neurometabolism and dopamine-signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N9F0; product specifications from Assay Genie datasheets.