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URB1
URB1 (URB1 ribosome biogenesis factor, also known as NPA1, KIAA0539 and C21orf108) is a nucleolar protein that binds RNA and is predicted to act in the maturation of ribosomal RNA. UniProt lists it as nucleolar pre-ribosomal-associated protein 1. Browse Assay Genie's current range of URB1 research reagents below, or read on for the biology behind the target.
URB1 is an RNA-binding protein associated with ribosome biogenesis. According to the NCBI Gene summary, it is predicted to be involved in the maturation of 5.8S rRNA and of large subunit rRNA (LSU-rRNA) from the tricistronic rRNA transcript, which contains the small subunit rRNA, 5.8S rRNA and LSU-rRNA. UniProt annotates the protein as nucleolar pre-ribosomal-associated protein 1 and places it in the nucleus, in the nucleolus, the site of ribosome assembly. The NCBI summary also describes it as located in the fibrillar centre.
The URB1 gene is classed by HGNC in three groups: armadillo like helical domain containing, ribosome biogenesis factors, and small nucleolar RNA protein coding host genes. The last group indicates that the locus also hosts small nucleolar RNA genes. The mouse ortholog is Urb1, which is useful for researchers designing comparative studies of the URB1 gene and its protein product.
The gene has had several names. Its aliases and previous symbols include KIAA0539, NPA1 and C21orf108, and earlier HGNC names include URB1 ribosome biogenesis 1 homolog (S. cerevisiae) and chromosome 21 open reading frame 108. These names are worth searching when reviewing older literature on URB1 and nucleolar pre-ribosomal-associated protein 1.
URB1 is classed as a ribosome biogenesis factor, making it relevant to studies of how ribosomal subunits are assembled.
URB1 is predicted to contribute to 5.8S rRNA and LSU-rRNA maturation from the tricistronic rRNA transcript.
URB1 localises to the nucleolus, with the NCBI summary noting the fibrillar centre, so it informs studies of nucleolar organisation.
URB1 enables RNA binding activity, which makes it a candidate for work on protein-RNA interactions in pre-ribosomal complexes.
URB1 enables RNA binding and is predicted to be involved in the maturation of 5.8S rRNA and LSU-rRNA from the tricistronic rRNA transcript. It is a nucleolar protein, and HGNC classifies it as a ribosome biogenesis factor.
URB1 is also known as NPA1, KIAA0539 and C21orf108. UniProt names the protein nucleolar pre-ribosomal-associated protein 1. Earlier HGNC names include URB1 ribosome biogenesis homolog and URB1 ribosome biogenesis 1 homolog (S. cerevisiae).
A mouse ortholog, Urb1, is recorded. The earlier HGNC name referring to the S. cerevisiae homolog points to a yeast counterpart. Check the datasheet of any product for its validated reactivity.
Other ribosome biogenesis factors and nucleolar proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60287; product specifications from Assay Genie datasheets.
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