KLK2
KLK2 (kallikrein related peptidase 2, formerly kallikrein 2, prostatic) is a glandular kallikrein and trypsin-like serine protease that cleaves selectively at arginine residues. It is primarily expressed in prostatic tissue and activates pro-prostate-specific antigen. Browse Assay Genie's current range of KLK2 research reagents below, or read on for the biology behind the target.
KLK2 is a highly active, trypsin-like serine protease that selectively cleaves at arginine residues. As a glandular kallikrein, it cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. It is also responsible for cleaving pro-prostate-specific antigen into its enzymatically active form, which links it directly to the biology of the prostate.
The KLK2 gene encodes a member of the glandular kallikrein protein family. Kallikreins are a subgroup of serine proteases clustered on chromosome 19, and members of the family are involved in a diverse array of biological functions. The protein belongs to the peptidase S1 family, kallikrein subfamily, and is classed by HGNC in the Kallikreins gene group. The protein is primarily expressed in prostatic tissue. Alternate splicing of the gene produces both coding and non-coding transcript variants. A rat ortholog, Klk2, is recorded in the data.
The gene is highly expressed in prostate tumour cells and may be a prognostic marker for prostate cancer risk, which is why KLK2 is often studied alongside prostate-specific antigen. Its previous HGNC name was kallikrein 2, prostatic. Researchers studying KLK2 commonly compare it with other kallikrein-related peptidases, such as KLK1 and KLK4, and with plasma kallikrein (KLKB1).
KLK2 is highly expressed in prostate tumour cells and may serve as a prognostic marker for prostate cancer risk.
KLK2 cleaves pro-prostate-specific antigen into its active form, making it relevant to prostatic protease cascades.
KLK2 is a trypsin-like serine protease that selectively cleaves at arginine residues, useful for studying substrate specificity.
Glandular kallikreins cleave kininogen to release Lys-bradykinin, connecting KLK2 to kinin generation.
KLK2 is a trypsin-like serine protease that cleaves selectively at arginine residues. It converts pro-prostate-specific antigen into its active form and, like other glandular kallikreins, cleaves kininogen at Met-Lys and Arg-Ser bonds to release Lys-bradykinin.
The HGNC name is kallikrein related peptidase 2, and the previous name was kallikrein 2, prostatic. UniProt lists the protein as Kallikrein-2 (EC 3.4.21.35). Alternate splicing of the KLK2 gene yields both coding and non-coding transcript variants.
KLK2 is highly expressed in prostate tumour cells and may be a prognostic marker for prostate cancer risk. A rat ortholog, Klk2, is recorded; no mouse ortholog is listed in the data, so check the datasheet of any product for its validated reactivity.
Other kallikrein-related peptidases and plasma kallikrein, plus related serine protease targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20151; product specifications from Assay Genie datasheets.