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TMEM237
TMEM237, or transmembrane protein 237, is a component of the transition zone in primary cilia and is required for ciliogenesis. It is also known as JBTS14 and ALS2CR4, and defects in the gene cause Joubert syndrome-14. Browse Assay Genie's current range of TMEM237 research reagents below, or read on for the biology behind the target.
TMEM237 is a component of the transition zone in primary cilia, the region at the base of the cilium that sits between the basal body and the axoneme. UniProt annotates the protein as required for ciliogenesis, so its presence is needed for primary cilia to form. It is classed as a membrane protein and is found in the cilium as a cell projection.
The protein encoded by the TMEM237 gene is described by NCBI Gene as a tetraspanin protein thought to be involved in WNT signalling. UniProt places it in the TMEM237 family. Two transcript variants encoding different isoforms have been reported for the gene. The mouse ortholog is Tmem237, which allows the protein to be studied in murine models of ciliary biology.
The gene was first named ALS2CR4, from the HGNC previous name amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4. It is now designated TMEM237 and is also known as JBTS14, reflecting its link to disease: defects in this gene are a cause of Joubert syndrome-14. Researchers working on ciliopathies, transition zone assembly and WNT-related signalling therefore use TMEM237 as a reference target, including in work that uses a TMEM237 antibody or TMEM237 protein reagents.
TMEM237 is required for ciliogenesis, making it a relevant target for studying how primary cilia are formed.
As a component of the transition zone in primary cilia, TMEM237 is used to study the composition of this ciliary compartment.
Defects in the TMEM237 gene cause Joubert syndrome-14, linking the protein to ciliopathy research.
TMEM237 is thought to be involved in WNT signalling, supporting studies of how ciliary proteins relate to this pathway.
TMEM237 is a component of the transition zone in primary cilia and is required for ciliogenesis. NCBI Gene also describes it as a tetraspanin protein thought to be involved in WNT signalling. It is a membrane protein located in the cilium.
TMEM237 is also known as JBTS14 and ALS2CR4. The latter derives from the previous name amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4. Two transcript variants encoding different isoforms have been found for the gene.
Defects in the TMEM237 gene are a cause of Joubert syndrome-14, hence the alias JBTS14. A mouse ortholog, Tmem237, exists. Check the datasheet of any product for its validated reactivity.
Other transmembrane proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96Q45; product specifications from Assay Genie datasheets.
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