PGC
PGC (progastricsin, also known as pepsinogen C) is the inactive zymogen of gastricsin, a secreted aspartic proteinase of the peptidase A1 family. It is a digestive enzyme produced in the stomach that hydrolyses a variety of proteins. Browse Assay Genie's current range of PGC research reagents below, or read on for the biology behind the target.
PGC encodes an aspartic proteinase of the peptidase A1 family. The mature enzyme, gastricsin, is a digestive protease that hydrolyses a variety of proteins. It is produced in the stomach and is a major component of the gastric mucosa, and it is also secreted into the serum.
The protein is synthesised as an inactive zymogen with a highly basic prosegment. At low pH, the prosegment is removed by sequential cleavage carried out by the enzyme itself, which converts the zymogen into its active mature form. This autoactivation couples enzyme activity to the acidic environment of the stomach. The PGC gene belongs to the HGNC pepsinogens group, and alternate splicing gives rise to multiple transcript variants. A pseudogene of this gene is found on chromosome 1. Orthologues are annotated in mouse and rat, both named Pgc.
The official name, progastricsin, reflects the zymogen precursor form, and the earlier name pepsinogen C remains in use in the literature. PGC is of clinical interest as well as biochemical interest. Polymorphisms in the PGC gene are associated with susceptibility to gastric cancers, and serum levels of the enzyme are used as a biomarker for certain gastric diseases, including Helicobacter pylori related gastritis. Researchers studying gastric physiology, zymogen activation or gastric disease may therefore look at PGC as an antibody target, an ELISA analyte or a recombinant protein.
Serum levels of PGC are used as a biomarker for certain gastric diseases, including Helicobacter pylori related gastritis.
Polymorphisms in the PGC gene are associated with susceptibility to gastric cancers, making it a candidate for genetic association studies.
PGC is made as an inactive zymogen and activated at low pH by self-catalysed cleavage of its basic prosegment.
PGC is a digestive enzyme produced in the stomach and forms a major component of the gastric mucosa.
PGC is the precursor of gastricsin, an aspartic proteinase of the peptidase A1 family that hydrolyses a variety of proteins. It is a digestive enzyme produced in the stomach and is also secreted into the serum. Active enzyme forms at low pH by self-cleavage of the prosegment.
PGC stands for progastricsin, previously named progastricsin (pepsinogen C). The mature protein is called gastricsin, and the enzyme carries EC number 3.4.23.3. The gene is placed in the HGNC pepsinogens group, and alternate splicing produces multiple transcript variants.
Polymorphisms in the PGC gene are associated with susceptibility to gastric cancers, and serum PGC is used as a biomarker for certain gastric diseases, including Helicobacter pylori related gastritis. Mouse and rat both have a Pgc ortholog; check the datasheet of any product for its validated reactivity.
Other pepsinogens, aspartic proteases and gastric markers that may be of interest alongside PGC.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20142; product specifications from Assay Genie datasheets.