SEMA4G
SEMA4G (semaphorin 4G, also known as FLJ20590 and KIAA1619) is a membrane-associated member of the semaphorin family. It acts as a cell surface receptor for PLXNB2 and may play a role in axon guidance. Browse Assay Genie's current range of SEMA4G research reagents below, or read on for the biology behind the target.
SEMA4G is a cell surface receptor for PLXNB2 and belongs to the semaphorin family. UniProt annotates a possible role in axon guidance, consistent with the wider function of semaphorins, which serve as axon guidance ligands through multimeric receptor complexes, some or all of which contain plexin proteins. The SEMA4G protein is localised to the cell membrane.
Semaphorins are a large family of conserved secreted and membrane-associated proteins. They share a semaphorin (Sema) domain and a PSI domain, a motif also found in plexins, semaphorins and integrins, in the N-terminal extracellular portion. On the basis of sequence and structural similarity they are divided into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. HGNC places the SEMA4G gene in the groups of immunoglobulin like domain containing genes, semaphorins, and microRNA protein coding host genes. A mouse ortholog, Sema4g, is recorded. NCBI Gene notes that multiple transcript variants encoding different isoforms have been found for this gene.
The approved name, semaphorin 4G, replaced the earlier descriptive name 'sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G', which summarises the domain architecture of the class 4 semaphorins. FLJ20590 and KIAA1619 are other names for the same gene. Researchers studying SEMA4G often work alongside other semaphorins and plexin signalling components when examining axon guidance mechanisms.
SEMA4G may play a role in axon guidance, and semaphorins in general act as guidance ligands through plexin-containing receptor complexes.
SEMA4G is a cell surface receptor for PLXNB2, making it relevant to studies of semaphorin-plexin interactions.
As a class 4 member of a conserved family defined by Sema and PSI domains, SEMA4G supports comparative work across semaphorin classes.
SEMA4G is localised to the cell membrane, and its domain architecture makes it a subject for cell surface protein research.
SEMA4G is a cell surface receptor for PLXNB2 and may play a role in axon guidance, according to UniProt. It belongs to the semaphorin family, whose members act as axon guidance ligands via multimeric receptor complexes, some or all of which contain plexin proteins.
SEMA4G is also known as FLJ20590 and KIAA1619, and its full name is semaphorin 4G. NCBI Gene reports that multiple transcript variants encoding different isoforms have been found for the SEMA4G gene, so check the datasheet of any product for its validated reactivity.
A mouse ortholog, Sema4g, is recorded. More broadly, semaphorins are described as a large family of conserved proteins, with vertebrates containing classes 3-7. SEMA4G sits within the class 4 semaphorins of this vertebrate group.
Other class 4 semaphorins and members of the wider semaphorin family involved in axon guidance, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NTN9; product specifications from Assay Genie datasheets.