TACR2
TACR2 (tachykinin receptor 2), also known as the Substance-K receptor, SKR, NK2R, TAC2R or NKNAR, is a G protein-coupled receptor for the neuropeptide substance K, also called neurokinin A. It signals through G proteins to drive second messenger pathways at the cell surface. Browse Assay Genie's current range of TACR2 research reagents below, or read on for the biology behind the target.
TACR2 is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It can also bind and respond to the tachykinins substance P and neurokinin B (neuromedin-K). The rank order of affinity is substance K, then neuromedin-K, then substance P. Binding of substance K activates G(q) and stimulates phosphatidylinositol hydrolysis by phospholipase C. It also activates adenylate cyclase, which raises intracellular cyclic AMP (cAMP) levels.
The TACR2 gene belongs to a family of genes that encode tachykinin receptors. Receptors in this family interact with G proteins and have seven hydrophobic transmembrane regions. According to the NCBI Gene summary, receptor affinities are specified by variations in the 5'-end of the sequence. The TACR2 protein is found at the cell membrane and belongs to the G protein-coupled receptor 1 family. In the HGNC classification it sits in the tachykinin receptors gene group, alongside TACR1 and TACR3.
Researchers studying tachykinin signalling often work with the TACR2 gene and protein to examine how receptor subtypes differ in ligand preference and in coupling to downstream pathways. Because TACR2 responds to more than one tachykinin, with a clear order of affinity, it is a useful model for ligand selectivity within a GPCR family. Mouse and rat both have a Tacr2 ortholog, which supports comparative work across species.
TACR2 is the receptor for substance K (neurokinin A) and also responds to substance P and neurokinin B, making it central to tachykinin biology.
Ligand binding activates G(q) and phospholipase C, and also adenylate cyclase with increased cAMP, so TACR2 illustrates dual G protein signalling.
The affinity order of substance K, then neuromedin-K, then substance P, makes TACR2 a reference for receptor-ligand selectivity.
TACR2 belongs to the tachykinin receptor group with TACR1 and TACR3, supporting comparison of subtype-specific roles and affinities.
TACR2 is a cell membrane receptor for substance K (neurokinin A). Ligand binding triggers G protein-coupled signalling through G(q), which activates phospholipase C and phosphatidylinositol hydrolysis, and through adenylate cyclase, which increases intracellular cAMP.
TACR2 is the HGNC symbol for tachykinin receptor 2. UniProt lists the protein as Substance-K receptor, and aliases include SKR, NK2R, TAC2R and NKNAR. Check the datasheet of any product for its validated reactivity and the name it uses.
Mouse and rat each have a Tacr2 ortholog. Human TACR2 binds substance K with highest affinity, then neuromedin-K (neurokinin B), then substance P. Check the datasheet of any product for its validated reactivity.
Other tachykinin receptors in the same HGNC gene group with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P21452; product specifications from Assay Genie datasheets.