DENND2B
DENND2B (DENN domain-containing protein 2B) is a DENN domain protein that may block ERK2 activation and may alter cell morphology and growth. It is also known as HTS1, p126 and ST5, the last from its original name, suppression of tumorigenicity 5. Browse Assay Genie's current range of DENND2B research reagents below, or read on for the biology behind the target.
DENND2B is annotated as a protein that may block ERK2 activation stimulated by ABL1, and that may alter cell morphology and cell growth. According to the NCBI Gene summary, the protein preferentially binds the SH3 domain of c-Abl kinase and acts as a regulator of MAPK1/ERK2 kinase. This activity may contribute to its ability to reduce the tumorigenic phenotype in cells, which makes it a useful subject for work on kinase signalling and growth control.
The DENND2B gene encodes a protein whose C-terminal region shares similarity with the Rab 3 family of small GTP-binding proteins. It belongs to the HGNC gene group of DENN domain containing proteins. UniProt records the protein in the cytoplasm at the cell cortex, at the cell membrane and in the recycling endosome. The mouse ortholog is Dennd2b. Three alternatively spliced transcript variants encoding distinct isoforms have been identified, so researchers studying the DENND2B protein should consider which isoform is relevant to their system.
The gene was identified by its ability to suppress the tumorigenicity of HeLa cells in nude mice. This origin explains the earlier name suppression of tumorigenicity 5 and the symbol ST5. Other aliases include HTS1 and p126. The current HGNC name, DENN domain containing 2B, reflects its place among DENN domain proteins.
DENND2B may block ERK2 activation stimulated by ABL1 and is described as a regulator of MAPK1/ERK2 kinase.
The gene was identified by its ability to suppress the tumorigenicity of HeLa cells in nude mice.
The protein preferentially binds the SH3 domain of c-Abl kinase, offering a route to study Abl-linked signalling.
DENND2B may alter cell morphology and cell growth, relevant to studies of cortical and membrane-associated regulation.
DENND2B may block ERK2 activation stimulated by ABL1 and may alter cell morphology and cell growth. It preferentially binds the SH3 domain of c-Abl kinase and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to reduced tumorigenic phenotype in cells.
DENND2B is also called HTS1, p126 and ST5, and was previously named suppression of tumorigenicity 5. The HGNC name is DENN domain containing 2B. Three alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
The gene was identified by its ability to suppress the tumorigenicity of HeLa cells in nude mice. Its regulation of MAPK1/ERK2 kinase may contribute to this effect. The mouse ortholog is Dennd2b; check the datasheet of any product for its validated reactivity.
Other DENN domain proteins, Abl and ERK pathway components and Rab family GTPases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78524; product specifications from Assay Genie datasheets.