ADH1C
ADH1C (alcohol dehydrogenase 1C, also known as ADH3) encodes the gamma subunit of class I alcohol dehydrogenase, a zinc-containing enzyme with high activity for ethanol oxidation. It plays a major role in ethanol catabolism. Browse Assay Genie's current range of ADH1C research reagents below, or read on for the biology behind the target.
ADH1C is an alcohol dehydrogenase that exhibits high activity for ethanol oxidation to acetaldehyde, and it plays a major role in ethanol catabolism. It belongs to the zinc-containing alcohol dehydrogenase family and is found in the cytoplasm. Members of this enzyme family metabolise a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products.
The ADH1C gene encodes the gamma subunit of class I alcohol dehydrogenase. Class I enzyme consists of several homo- and heterodimers of alpha, beta and gamma subunits, so the ADH1C protein functions as part of dimeric assemblies with related subunits. The genes for the alpha, beta and gamma subunits (ADH1A, ADH1B and ADH1C) are tandemly organised in a genomic segment as a gene cluster. HGNC places the gene in the alcohol dehydrogenases group.
ADH1C was previously known by the symbol ADH3. Researchers studying ethanol metabolism, retinol and aliphatic alcohol handling, or the class I subunit composition often work with the ADH1C gene and protein alongside its cluster neighbours. An association between ADH1C polymorphism and alcohol dependence has not been established, according to the NCBI Gene summary.
ADH1C exhibits high activity for ethanol oxidation to acetaldehyde and plays a major role in ethanol catabolism.
As the gamma subunit of class I enzyme, ADH1C helps define how alpha, beta and gamma subunits form homo- and heterodimers.
The alcohol dehydrogenase family metabolises retinol, hydroxysteroids and lipid peroxidation products, placing ADH1C within wider substrate-handling research.
ADH1C polymorphism has been examined in relation to alcohol dependence, although an association has not been established.
ADH1C encodes the gamma subunit of class I alcohol dehydrogenase. The enzyme shows high activity for oxidising ethanol to acetaldehyde and plays a major role in ethanol catabolism. The wider family also acts on retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products.
ADH1C is the current HGNC symbol for alcohol dehydrogenase 1C (class I), gamma polypeptide. The earlier symbol was ADH3. The protein is the gamma subunit of class I alcohol dehydrogenase, which assembles with alpha and beta subunits as homo- and heterodimers.
ADH1C belongs to the zinc-containing alcohol dehydrogenase family. The genes encoding the alpha, beta and gamma class I subunits (ADH1A, ADH1B and ADH1C) lie together as a tandemly organised gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established.
Other alcohol dehydrogenases, including the class I alpha and beta subunits encoded alongside ADH1C, and related alcohol-metabolising enzymes.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P00326; product specifications from Assay Genie datasheets.