CORIN
CORIN (corin, serine peptidase) is a type II transmembrane serine protease that converts pro-atrial natriuretic peptide into its active form, a cardiac hormone involved in blood volume and pressure control. It is also known as atrial natriuretic peptide-converting enzyme, PRSC, CRN, ATC2, Lrp4 and TMPRSS10. Browse Assay Genie's current range of CORIN research reagents below, or read on for the biology behind the target.
CORIN is a serine protease that processes natriuretic peptide precursors. According to the NCBI Gene summary, the encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. The protein may also function as a pro-brain-type natriuretic peptide convertase. This proteolytic activation step places CORIN within the natriuretic peptide pathway that is studied in cardiovascular biology.
The CORIN gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily, and the protein belongs to the peptidase S1 family. Members of this family are composed of multiple structurally distinct domains. HGNC places CORIN in the groups of scavenger receptor cysteine rich domain containing proteins and type II transmembrane serine proteases. UniProt lists subcellular locations as the cell membrane and secreted, and assigns the enzyme class EC 3.4.21.-. Mouse and rat both have a Corin ortholog.
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. UniProt notes that one isoform has weaker endopeptidase activity than isoform 1. The gene has appeared under several names, including the previous name corin, serine protease, and the symbols PRSC, CRN, ATC2, Lrp4 and TMPRSS10, which is worth bearing in mind when searching the literature for a CORIN antibody, CORIN ELISA kit or CORIN protein.
CORIN converts pro-atrial natriuretic peptide to its active form and may act on pro-brain-type natriuretic peptide, making it central to studies of this hormone pathway.
The active atrial natriuretic peptide generated by CORIN regulates blood volume and pressure, so the protease is relevant to cardiovascular regulation research.
As the enzyme that activates a cardiac hormone, CORIN is studied in the context of how the heart signals to regulate circulation.
A multi-domain type II transmembrane member of the trypsin superfamily, CORIN is a model for studying peptidase S1 family structure and isoform activity.
CORIN is a type II transmembrane serine protease that converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone regulating blood volume and pressure. It may also act as a pro-brain-type natriuretic peptide convertase.
CORIN is also called atrial natriuretic peptide-converting enzyme, PRSC, CRN, ATC2, Lrp4 and TMPRSS10, and was previously named corin, serine protease. Multiple alternatively spliced transcript variants encode different isoforms, one of which has weaker endopeptidase activity than isoform 1.
Yes. Mouse and rat both carry a Corin ortholog of the human gene. Researchers working in these species should check the datasheet of any product for its validated reactivity.
Natriuretic peptides, their receptors and other transmembrane serine proteases studied alongside CORIN.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5Q5; product specifications from Assay Genie datasheets.