PARM1
PARM1 (prostate androgen-regulated mucin-like protein 1) is a membrane-associated protein of the PARM family. It may regulate TLP1 expression and telomerase activity, and is also known as DKFZP564O0823, Cipar1 and WSC4. Browse Assay Genie's current range of PARM1 research reagents below, or read on for the biology behind the target.
PARM1 is annotated as a protein that may regulate TLP1 expression and telomerase activity. Through this role it may enable certain prostatic cells to resist apoptosis. The annotation is cautious, and the molecular mechanism behind this proposed function is not described in the source data, so it is best treated as a working hypothesis for experimental study.
The PARM1 protein belongs to the PARM family. It is located in the cell membrane, the Golgi apparatus membrane and the endosome membrane, which places it within compartments linked to membrane trafficking as well as the cell surface. The human gene is symbolised PARM1 by HGNC, and orthologues are designated Parm1 in both mouse and rat, which allows comparative work in rodent models.
The name reflects the early association of the protein with prostate tissue and androgen regulation, with a mucin-like designation. The gene has also been recorded under the aliases DKFZP564O0823, Cipar1 and WSC4, so literature searches for PARM1 may benefit from including these terms. Researchers studying the PARM1 gene or its protein product will find the subcellular localisation data useful when designing imaging and fractionation experiments.
PARM1 is proposed to help certain prostatic cells resist apoptosis, making it a candidate for studies of prostate cell survival.
PARM1 may regulate telomerase activity and TLP1 expression, linking it to studies of telomere-associated pathways.
Its suggested role in enabling cells to resist apoptosis makes PARM1 relevant to research on cell survival mechanisms.
PARM1 localises to the plasma membrane, Golgi apparatus and endosomes, supporting studies of its distribution across membrane compartments.
According to UniProt, PARM1 may regulate TLP1 expression and telomerase activity, thereby enabling certain prostatic cells to resist apoptosis. The wording is tentative. The protein is found in the cell membrane, Golgi apparatus membrane and endosome membrane.
PARM1 stands for prostate androgen-regulated mucin-like protein 1. Aliases and previous symbols include DKFZP564O0823, Cipar1 and WSC4. The protein is a member of the PARM family, and it is useful to search these alternative names when reviewing the literature.
Yes. Mouse and rat both have an orthologue named Parm1, so the gene can be studied in rodent systems. Researchers should check the datasheet of any product for its validated reactivity before using it with a given species.
Other prostate-associated proteins, membrane proteins and apoptosis-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UWI2; product specifications from Assay Genie datasheets.