CEBPE
CEBPE (CCAAT/enhancer-binding protein epsilon, also known as CRP1) is a nuclear bZIP transcription factor of the C/EBP subfamily. It activates transcription and is required for myeloid differentiation, particularly the progression of granulocyte precursors. Browse Assay Genie's current range of CEBPE research reagents below, or read on for the biology behind the target.
CEBPE is a transcriptional activator. Like other C/EBP proteins, it is a DNA-binding protein that recognises two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. It is required for the promyelocyte-myelocyte transition in myeloid differentiation, and is thought to be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells.
The protein belongs to the bZIP family and the C/EBP subfamily, and is classed by HGNC in the CCAAT/enhancer binding proteins gene group. It is found in the nucleus. The CEBPE gene encodes a bZIP transcription factor that can bind certain DNA regulatory regions as a homodimer, and it can also form heterodimers with the related protein CEBP-delta. Multiple variants of the gene have been described, although the full-length nature of only one has been determined. Orthologous genes are named Cebpe in both mouse and rat.
The gene was previously named CCAAT/enhancer binding protein (C/EBP), epsilon, and the symbol CRP1 is a recorded alias. Mutations in CEBPE have been associated with Specific Granule Deficiency, a rare congenital disorder, which makes the CEBPE protein a relevant subject for studies of granulocyte development and the transcriptional control of myeloid differentiation.
CEBPE is required for the promyelocyte-myelocyte transition, making it a key factor for studying how myeloid lineage cells progress through differentiation.
The protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells.
As a bZIP factor recognising CCAAT and enhanced core motifs, CEBPE is used to explore promoter and enhancer regulation.
Mutations in the CEBPE gene are associated with Specific Granule Deficiency, a rare congenital disorder.
CEBPE is a transcriptional activator that binds DNA at CCAAT homology motifs found in many promoters and at enhanced core homology motifs found in many enhancers. It is required for the promyelocyte-myelocyte transition during myeloid differentiation and supports granulocyte progenitor maturation.
CEBPE is also known as CRP1 and was previously named CCAAT/enhancer binding protein (C/EBP), epsilon. It binds DNA as a homodimer and can form heterodimers with the related protein CEBP-delta. Multiple variants have been described, but only one full-length form has been determined.
Mutations in the CEBPE gene are associated with Specific Granule Deficiency, a rare congenital disorder. Mouse and rat both carry a Cebpe ortholog, so rodent systems can be relevant; check the datasheet of any product for its validated reactivity.
Other C/EBP family transcription factors, including the heterodimer partner CEBP-delta, and related regulators of myeloid differentiation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15744; product specifications from Assay Genie datasheets.