NLGN1
NLGN1 (neuroligin 1, also known as KIAA1070 or NLG1) is a neuronal cell surface protein that interacts with neurexin family members. It contributes to synapse function and synaptic signal transmission in the nervous system. Browse Assay Genie's current range of NLGN1 research reagents below, or read on for the biology behind the target.
NLGN1 is a cell surface protein involved in cell-cell interactions through its binding to members of the neurexin family. It plays a role in synapse function and synaptic signal transmission, and is thought to act by recruiting and clustering other synaptic proteins. RefSeq describes members of this family as possible splice site-specific ligands for beta-neurexins, with a potential role in the formation and remodelling of central nervous system synapses.
Functional studies described in UniProt indicate that NLGN1 may promote the initial formation of synapses, although it is not essential for this. In vitro, it triggers the de novo formation of presynaptic structures, and it may be involved in the specification of excitatory synapses. The protein is also required to maintain wakefulness quality and the normal synchrony of cerebral cortex activity during wakefulness and sleep, and it is involved in nervous system development.
The NLGN1 gene encodes Neuroligin-1, which belongs to the neuroligin gene group and to the type-B carboxylesterase/lipase family. UniProt places the protein in the cell membrane, including the synaptic cell membrane, postsynaptic density, synaptic cleft and dendrites. Researchers studying the NLGN1 protein often examine it alongside other neuroligins such as NLGN3 and NLGN4X. The mouse and rat orthologues are both named Nlgn1.
NLGN1 may promote the initial formation of synapses and triggers presynaptic structure formation in vitro, making it a focus for synaptogenesis studies.
NLGN1 interacts with neurexin family members, and may act as a splice site-specific ligand for beta-neurexins, in trans-synaptic adhesion.
NLGN1 may be involved in specifying excitatory synapses and in recruiting and clustering other synaptic proteins.
NLGN1 is involved in nervous system development and in maintaining wakefulness quality and cortical synchrony during wakefulness and sleep.
NLGN1 is a cell surface protein that interacts with neurexins and contributes to synapse function and synaptic signal transmission. It probably acts by recruiting and clustering other synaptic proteins, and it may be involved in specifying excitatory synapses.
The NLGN1 gene, neuroligin 1, is also known as KIAA1070 and NLG1. UniProt names the protein Neuroligin-1. HGNC classifies it in the neuroligins gene group, and UniProt places it in the type-B carboxylesterase/lipase family.
Yes. Mouse and rat both have an orthologue named Nlgn1, so findings in rodent models are often relevant to the human protein. Check the datasheet of any product for its validated reactivity.
Other neuroligin family members and synaptic adhesion proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N2Q7; product specifications from Assay Genie datasheets.