NDNF
NDNF (neuron derived neurotrophic factor, also known as FLJ23191 or C4orf31) is a secreted protein that influences neuronal migration, growth and survival. It also contributes to extracellular matrix organisation and to endothelial cell survival and vessel formation. Browse Assay Genie's current range of NDNF research reagents below, or read on for the biology behind the target.
NDNF is a secretory protein that acts in several cellular processes. In the developing nervous system it behaves as a chemorepellent for gonadotropin-releasing hormone (GnRH) expressing neurons, regulating their migration to the hypothalamus. It also promotes neuron migration, growth and survival, supports neurite outgrowth, and is involved in development of the olfactory system. UniProt notes that it may also act by regulating growth factor activity and downstream signalling.
Outside the nervous system, NDNF regulates extracellular matrix assembly and cell adhesiveness. It promotes endothelial cell survival and vessel formation, and plays an important role in revascularisation through NOS3-dependent mechanisms. The NCBI Gene summary adds involvement in the cellular response to hypoxia, negative regulation of apoptotic process and nitric oxide mediated signal transduction. The NDNF protein is predicted to bind heparin and is located in the extracellular region.
The human NDNF gene lies at 4q27 and was formerly designated chromosome 4 open reading frame 31 (C4orf31); FLJ23191 is a further alias. A mouse ortholog, Ndnf, is recorded. NDNF is implicated in hypogonadotropic hypogonadism, consistent with its role in guiding GnRH neuron migration. Researchers studying NDNF commonly work on neurodevelopment, vascular biology and hypoxia responses, where its secreted nature makes it relevant to extracellular signalling.
NDNF repels GnRH expressing neurons and promotes neuron migration, growth and survival, making it a useful factor for studying neural development.
NDNF is involved in development of the olfactory system, linking it to the wiring of olfactory and GnRH neuron pathways.
NDNF promotes endothelial cell survival and vessel formation, and supports revascularisation through NOS3-dependent mechanisms.
NDNF is implicated in hypogonadotropic hypogonadism, connecting its role in GnRH neuron migration to reproductive endocrine disorders.
NDNF is a secreted protein that acts as a chemorepellent for GnRH expressing neurons and promotes neuron migration, growth, survival and neurite outgrowth. It also regulates extracellular matrix assembly and cell adhesiveness, and promotes endothelial cell survival and vessel formation through NOS3-dependent mechanisms.
NDNF stands for neuron derived neurotrophic factor. Its aliases include FLJ23191 and C4orf31, the latter being a previous symbol derived from the earlier name chromosome 4 open reading frame 31. UniProt lists the recommended protein name as Protein NDNF.
NDNF is implicated in hypogonadotropic hypogonadism, in line with its role in GnRH neuron migration to the hypothalamus. A mouse ortholog, Ndnf, exists; check the datasheet of any product for its validated reactivity.
Neurotrophic factors, angiogenesis regulators and hypoxia pathway proteins related to NDNF biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TB73; product specifications from Assay Genie datasheets.