TCN1
TCN1 (transcobalamin 1, also known as TCI or TC1) is a secreted vitamin B12-binding protein of the R binder family. It binds cobalamin with femtomolar affinity and is a major constituent of secondary granules in neutrophils. Browse Assay Genie's current range of TCN1 research reagents below, or read on for the biology behind the target.
TCN1 binds vitamin B12 (cobalamin) with femtomolar affinity and protects it from the acidic environment of the stomach. According to NCBI Gene, the protein also facilitates the transport of cobalamin into cells. This combination of tight binding and protection defines its role as a cobalamin carrier in secretions and tissues.
The TCN1 gene encodes a member of the vitamin B12-binding protein family, which UniProt places in the eukaryotic cobalamin transport proteins family. Proteins in this group are alternatively referred to as R binders and are expressed in various tissues and secretions. TCN1 is a secreted protein and is a major constituent of secondary granules in neutrophils, linking cobalamin handling to myeloid cell biology.
The protein has historically been called transcobalamin I, with the longer descriptive name transcobalamin I (vitamin B12 binding protein, R binder family). The symbols TCI and TC1 are previous designations that you may still see in older literature. Researchers studying cobalamin transport often consider TCN1 alongside TCN2, the related transcobalamin gene, when examining how vitamin B12 is carried and delivered. Whether you work with a TCN1 antibody, a TCN1 ELISA kit or recombinant TCN1 protein, the biology centres on secreted cobalamin binding and neutrophil granule content.
TCN1 binds cobalamin with femtomolar affinity and facilitates its transport into cells, making it a key protein for studying B12 handling.
TCN1 is a major constituent of secondary granules in neutrophils, so it is relevant to studies of granule content and myeloid cells.
TCN1 protects bound vitamin B12 from the acidic environment of the stomach, informing work on cobalamin stability in digestion.
As an R binder, TCN1 is expressed in various tissues and secretions, supporting comparative work across the cobalamin-binding protein family.
TCN1 is a secreted protein that binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. NCBI Gene also reports that it facilitates the transport of cobalamin into cells and is a major constituent of neutrophil secondary granules.
TCN1 is the approved symbol for transcobalamin 1. Previous symbols are TCI and TC1, and earlier names include transcobalamin I and transcobalamin I (vitamin B12 binding protein, R binder family). The protein is also called an R binder, after the family it belongs to.
TCN1 belongs to the eukaryotic cobalamin transport proteins family, also described as the vitamin B12-binding or R binder family. Members are expressed in various tissues and secretions. TCN2 is a related transcobalamin gene often studied alongside TCN1 in cobalamin transport research.
Related transcobalamin and cobalamin-transport targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20061; product specifications from Assay Genie datasheets.