SEMA4C
SEMA4C (semaphorin 4C) is a member of the semaphorin family that acts as a cell surface receptor for PLXNB2 in cell-cell signalling. It is also known as Semacl1, Semaf and SemaI. Browse Assay Genie's current range of SEMA4C research reagents below, or read on for the biology behind the target.
SEMA4C is a cell surface receptor for PLXNB2 and plays an important role in cell-cell signalling. Binding of PLXNB2 promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. The protein is required for normal brain development, axon guidance and cell migration. It is also a probable signalling receptor that may contribute to myogenic differentiation through activation of the stress-activated MAPK cascade.
The SEMA4C gene encodes semaphorin-4C, which belongs to the semaphorin family. In HGNC it is placed in the groups of immunoglobulin like domain containing proteins and semaphorins. UniProt records the protein at the postsynaptic density membrane and in the membrane of synaptic vesicles, a cytoplasmic secretory vesicle compartment. The mouse ortholog is Sema4c.
NCBI Gene summary annotations, provided by the Alliance of Genome Resources, predict that SEMA4C enables chemorepellent activity, neuropilin binding and semaphorin receptor binding. The gene is also linked to muscle cell differentiation and to positive regulation of the stress-activated MAPK cascade. The earlier HGNC name describes its domain layout: a sema domain, an immunoglobulin domain, a transmembrane domain and a short cytoplasmic domain. Alternative symbols include Semacl1, Semaf and SEMAI, which may appear in older literature on the SEMA4C protein and gene.
SEMA4C is required for normal brain development, making it a relevant target for studies of how semaphorin signalling shapes the developing nervous system.
Its role in axon guidance and predicted chemorepellent activity make SEMA4C useful for examining how guidance cues direct neuronal growth.
SEMA4C is required for normal cell migration, and PLXNB2 binding drives RHOA activation, linking it to migration signalling pathways.
SEMA4C may influence myogenic differentiation through the stress-activated MAPK cascade, supporting work on muscle cell differentiation mechanisms.
SEMA4C is a cell surface receptor for PLXNB2 involved in cell-cell signalling. PLXNB2 binding promotes RHOA activation and ERBB2 phosphorylation at Tyr-1248. It is required for normal brain development, axon guidance and cell migration, and may contribute to myogenic differentiation via the stress-activated MAPK cascade.
The HGNC name is semaphorin 4C, and UniProt lists semaphorin-4C. Aliases and previous symbols include Semacl1, Semaf and SEMAI. The older HGNC name describes a sema domain, an immunoglobulin domain, a transmembrane domain and a short cytoplasmic domain.
A mouse ortholog, Sema4c, is recorded for the human gene. The source data give no rat ortholog. Researchers should check the datasheet of any product for its validated reactivity before using it in a given species.
Other semaphorin family members involved in axon guidance, cell migration and cell-cell signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9C0C4; product specifications from Assay Genie datasheets.