EIF5A2
EIF5A2 (eukaryotic translation initiation factor 5A2) is a member of the eIF-5A family of translation factors. It promotes translation elongation and termination, particularly when ribosomes stall at difficult amino acid sequence contexts such as polyproline stretches. Browse Assay Genie's current range of EIF5A2 research reagents below, or read on for the biology behind the target.
EIF5A2 is a translation factor that promotes translation elongation and termination, particularly when the ribosome stalls at specific amino acid sequence contexts. The protein binds between the exit (E) and peptidyl (P) sites of the ribosome and helps rescue stalled ribosomes. It is specifically required for efficient translation of polyproline-containing peptides, as well as other motifs that cause stalling.
EIF5A2 also acts as a ribosome quality control (RQC) cofactor. It joins the RQC complex to facilitate peptidyl transfer during the CAT tailing step. Beyond the ribosome, UniProt annotates roles for the protein in actin dynamics, cell cycle progression and mRNA decay. It is also probably involved in a pathway for stress response and maintenance of cell wall integrity.
The human EIF5A2 gene encodes a protein that belongs to the eIF-5A family. UniProt records it in the cytoplasm, the nucleus and the endoplasmic reticulum membrane. NCBI Gene describes it as predicted to enable translation elongation factor activity and to be involved in translational elongation, with a predicted cytosolic location. The mouse ortholog is Eif5a2. Researchers studying the EIF5A2 gene or protein often consider it alongside EIF5A, the other eIF-5A family member with a page on this site, and the wider set of eukaryotic initiation factors.
EIF5A2 promotes elongation and termination, so it is relevant to work on how ribosomes pass difficult sequence contexts.
It binds between the E and P sites and is required for efficient translation of polyproline-containing peptides.
EIF5A2 acts as an RQC cofactor, joining the RQC complex to facilitate peptidyl transfer during CAT tailing.
UniProt links the protein to actin dynamics, cell cycle progression, mRNA decay and a probable stress response pathway.
EIF5A2 is a translation factor that promotes elongation and termination, especially when ribosomes stall. It binds between the ribosomal E and P sites and is needed for efficient translation of polyproline-containing peptides. It also works as a ribosome quality control cofactor during CAT tailing.
EIF5A2 stands for eukaryotic translation initiation factor 5A2, and UniProt names the protein eukaryotic translation initiation factor 5A-2. No aliases or previous symbols are listed in the data. It belongs to the eIF-5A family.
The mouse ortholog is Eif5a2. The protein belongs to the eIF-5A family, which also includes EIF5A. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Other eIF-5A family members, eukaryotic initiation factors and translation-control proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9GZV4; product specifications from Assay Genie datasheets.