SFTPC
SFTPC (surfactant protein C, also known as SP-C, PSP-C, SMDP2, BRICD6 and SFTP2) is an extremely hydrophobic surfactant protein that is essential for lung function after birth. It promotes alveolar stability by lowering surface tension at the air-liquid interface. Browse Assay Genie's current range of SFTPC research reagents below, or read on for the biology behind the target.
SFTPC encodes surfactant protein C, one of the proteins of pulmonary surfactant. Pulmonary surfactant is a surface-active lipoprotein complex made up of about 90% lipids and 10% proteins, including the surfactant proteins SPA, SPB, SPC and SPD. It is secreted by the alveolar cells of the lung and coats the fluids lining the air spaces. By reducing surface tension at the air-liquid interface in the peripheral air spaces, surfactant protein C helps maintain the stability of alveoli and of pulmonary tissue. The protein is found in the extracellular space as part of the surface film.
The SFTPC gene produces an extremely hydrophobic protein and is classed by HGNC in the BRICHOS domain containing group, which is reflected in the alias BRICD6. Alternatively spliced transcript variants encoding different protein isoforms have been identified. Mouse and rat both have an orthologous gene, Sftpc, so the target can be studied in common rodent models of lung biology.
Aliases include SP-C, PSP-C, SMDP2 and SFTP2, and earlier gene names were surfactant, pulmonary-associated protein C. Multiple mutations in the SFTPC gene have been identified. They cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children and adults. This makes SFTPC a frequently studied marker and disease gene in respiratory research.
SFTPC is a core surfactant protein that lowers surface tension at the air-liquid interface, making it central to studies of alveolar stability.
Mutations in the SFTPC gene are associated with interstitial lung disease in infants, children and adults.
SFTPC mutations cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency.
Surfactant is secreted by alveolar cells, so SFTPC is relevant to work on lung homeostasis and function after birth.
SFTPC encodes surfactant protein C, an extremely hydrophobic component of pulmonary surfactant. Surfactant proteins promote alveolar stability by lowering surface tension at the air-liquid interface in the peripheral air spaces. The protein is essential for lung function and homeostasis after birth.
SFTPC is also known as SP-C, PSP-C, SMDP2, BRICD6 and SFTP2, and was previously named surfactant, pulmonary-associated protein C. NCBI Gene reports alternatively spliced transcript variants that encode different protein isoforms.
Yes. Mutations in SFTPC cause pulmonary surfactant metabolism dysfunction type 2 and are associated with interstitial lung disease. Mouse and rat each have an ortholog named Sftpc. Check the datasheet of any product for its validated reactivity.
Other surfactant proteins and lung biology targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11686; product specifications from Assay Genie datasheets.