SEMA3B
SEMA3B (semaphorin 3B) is a secreted class-3 semaphorin that inhibits axonal extension by marking territories that growing axons cannot enter. Also known as SemA, semaV, LUCA-1, sema5 and SEMAA, it has also been shown to act as a tumour suppressor. Browse Assay Genie's current range of SEMA3B research reagents below, or read on for the biology behind the target.
SEMA3B is a member of the semaphorin family and, more specifically, of the class-3 semaphorin/collapsin group, whose members function in growth cone guidance during neuronal development. The protein inhibits axonal extension by providing local signals that specify territories inaccessible to growing axons. In this way it helps define the boundaries within which developing neurons can extend their processes.
UniProt records the SEMA3B protein as Semaphorin-3B, with subcellular locations in the secreted fraction and the endoplasmic reticulum. The SEMA3B gene lies at 3p21.31, and alternative splicing results in multiple transcript variants. The mouse ortholog is Sema3b. HGNC places the gene in the groups of immunoglobulin like domain containing genes, semaphorins, and microRNA protein coding host genes.
Beyond neuronal guidance, the NCBI Gene summary notes that SEMA3B has been shown to act as a tumour suppressor by inducing apoptosis. This dual role makes the SEMA3B protein relevant to both developmental neurobiology and cancer research. The gene has appeared under several names, including SemA, semaV, LUCA-1, sema5 and SEMAA, and its earlier HGNC name was sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B. Researchers studying SEMA3B often compare it with other class-3 semaphorins and with semaphorins from other classes.
SEMA3B inhibits axonal extension and specifies territories inaccessible to growing axons, making it a tool for studying growth cone guidance.
As a class-3 semaphorin, SEMA3B functions in growth cone guidance during neuronal development.
SEMA3B has been shown to act as a tumour suppressor by inducing apoptosis, supporting cancer biology investigations.
SEMA3B belongs to the semaphorin family, so it is often studied alongside other class-3 members and related semaphorins.
SEMA3B inhibits axonal extension by providing local signals that specify territories inaccessible to growing axons. As a class-3 semaphorin it functions in growth cone guidance during neuronal development, and it has also been shown to act as a tumour suppressor by inducing apoptosis.
SEMA3B is also known as semaphorin 3B, Semaphorin-3B, SemA, semaV, LUCA-1, sema5 and SEMAA. Alternative splicing of the gene results in multiple transcript variants, so literature and datasheets may refer to more than one transcript.
The mouse ortholog of human SEMA3B is Sema3b, which allows the protein's role in neuronal guidance to be studied in mouse models. Check the datasheet of any product for its validated reactivity.
Other class-3 semaphorins and semaphorin family members involved in axon guidance and neuronal development, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13214; product specifications from Assay Genie datasheets.