ZNF875
ZNF875 (zinc finger protein 875) is a nuclear member of the Krüppel C2H2-type zinc-finger protein family that may be involved in transcriptional regulation. It was previously known as HKR1, GLI-Kruppel family member HKR1. Browse Assay Genie's current range of ZNF875 research reagents below, or read on for the biology behind the target.
ZNF875 is annotated in UniProt as a protein that may be involved in transcriptional regulation. Its function has not been defined experimentally in the supplied sources. Gene annotation from the Alliance of Genome Resources predicts that it enables DNA-binding transcription factor activity specific to RNA polymerase II, including sequence-specific binding to RNA polymerase II transcription regulatory regions. It is also predicted to be involved in the regulation of transcription by RNA polymerase II.
The ZNF875 protein belongs to the Krüppel C2H2-type zinc-finger protein family. In HGNC it is classified within two gene groups: zinc fingers C2H2-type and KRAB domain containing. The protein is localised to the nucleus, consistent with a role in regulating gene expression, and it is predicted to be active there.
The ZNF875 gene was formerly named HKR1, and earlier HGNC names include GLI-Kruppel family member HKR1 and HKR1, GLI-Kruppel zinc finger family member. These names reflect its relationship to the GLI-Krüppel group of zinc finger proteins. Because much of the available information is predicted rather than experimentally established, ZNF875 remains a candidate for studies of DNA-binding and transcriptional regulation in the zinc finger family.
ZNF875 is predicted to act as a DNA-binding transcription factor in RNA polymerase II-dependent transcription, making it a candidate for gene regulation research.
As a Krüppel C2H2-type protein with a KRAB domain classification, ZNF875 offers a model for studying this large transcription factor family.
ZNF875 is a nuclear protein, so it is relevant to work on nuclear compartments and the localisation of transcriptional regulators.
Its function is only predicted, so ZNF875 is a target for experiments that test its DNA-binding activity and regulatory role.
UniProt states that ZNF875 may be involved in transcriptional regulation. Gene annotation predicts that it has DNA-binding transcription factor activity and binds sequence-specific regulatory regions for RNA polymerase II. These roles are predicted rather than experimentally confirmed, and the protein is localised to the nucleus.
ZNF875 was previously designated HKR1. Earlier HGNC names were GLI-Kruppel family member HKR1 and HKR1, GLI-Kruppel zinc finger family member. The current approved name is zinc finger protein 875. Check these aliases when searching literature or reading product information.
ZNF875 belongs to the Krüppel C2H2-type zinc-finger protein family. HGNC places it in the zinc fingers C2H2-type group and the KRAB domain containing group. Mouse and rat orthologs are not listed in the data supplied, so check the datasheet of any product for its validated reactivity.
Other zinc finger proteins and putative transcriptional regulators from the C2H2-type and KRAB-containing groups.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10072; product specifications from Assay Genie datasheets.