H2BC21
H2BC21 (H2B clustered histone 21, also known as H2BE, H2B-GL105 and HIST2H2BE) encodes histone H2B type 2-E, a replication-dependent core histone of the H2B family. Beyond its role in nucleosome structure, the protein has antibacterial and antifungal activity. Browse Assay Genie's current range of H2BC21 research reagents below, or read on for the biology behind the target.
Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fibre in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3 and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes. The linker histone H1 interacts with the linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. H2BC21 protein is one of the H2B components of this core octamer.
The H2BC21 gene encodes a replication-dependent histone belonging to the histone H2B family and is classified by HGNC in the H2B histones gene group. It generates two transcripts through use of the conserved stem-loop termination motif and the polyA addition motif. The protein localises to the nucleus and chromosomes. A mouse ortholog, H2bc21, is recorded for the gene.
In addition to its chromatin role, the protein has broad antibacterial activity and has been described as having antifungal antimicrobial activity. It may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. The gene has appeared under several earlier names, including histone cluster 2 H2B family member e, HIST2H2BE and H2B histone family, member Q (H2BFQ), reflecting the revision of histone gene nomenclature.
As a core histone, H2BC21 contributes to the nucleosome octamer around which DNA is wrapped, making it relevant to studies of chromatin structure.
The protein has broad antibacterial activity and reported antifungal activity, so it is studied as a component of innate antimicrobial defence.
H2BC21 may contribute to the functional antimicrobial barrier of the colonic epithelium, linking a histone to mucosal defence research.
The protein may contribute to the bactericidal activity of amniotic fluid, a topic of interest in studies of antimicrobial protection during gestation.
H2BC21 encodes histone H2B type 2-E, a core histone that helps form the nucleosome octamer around which DNA is wrapped. The protein also has antibacterial and antifungal activity and may contribute to antimicrobial barriers such as the colonic epithelium and amniotic fluid.
H2BC21 is also called H2BE, H2B-GL105, H2B.1, H2B/q, H2BFQ and HIST2H2BE. Previous names include histone cluster 2 H2B family member e and H2B histone family, member Q. The UniProt protein name is histone H2B type 2-E.
The gene has a mouse ortholog, H2bc21, and belongs to the widely conserved histone H2B family found in eukaryotes. No rat ortholog is given in the data here. Check the datasheet of any product for its validated reactivity.
Other core and linker histones and H2B family members that contribute to nucleosome and chromatin research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16778; product specifications from Assay Genie datasheets.