HRH1
HRH1 (histamine receptor H1) is a G protein-coupled receptor for histamine, a biogenic amine that acts as an immune modulator and a neurotransmitter. Also called the histamine H1 receptor, it mediates smooth muscle contraction, vascular permeability changes and neurotransmission in the central nervous system. Browse Assay Genie's current range of HRH1 research reagents below, or read on for the biology behind the target.
HRH1 is a G protein-coupled receptor for histamine. Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability, which results from contraction of terminal venules. The receptor also mediates the release of catecholamine from the adrenal medulla. In the central nervous system it mediates neurotransmission and thereby regulates circadian rhythms, emotional and locomotor activities and cognitive functions.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells and neurons. Its actions are mediated by four receptors, H1, H2, H3 and H4. The protein encoded by the HRH1 gene is an integral membrane protein located at the cell membrane and belongs to the G protein-coupled receptor 1 family. It is a member of the HGNC gene group of histamine receptors, alongside HRH2, HRH3 and HRH4. Mouse and rat both carry an orthologous gene, Hrh1. Multiple alternatively spliced variants have been identified, and they encode the same protein.
Beyond its roles in smooth muscle and neurotransmission, the histamine H1 receptor has been associated with memory and learning, circadian rhythm and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases, including atopic dermatitis, asthma, anaphylaxis and allergic rhinitis, which makes it a frequent subject in allergy and immunology research.
HRH1 contributes to the pathophysiology of atopic dermatitis, asthma, anaphylaxis and allergic rhinitis, and histamine acts as an immune modulator.
The receptor mediates central nervous system neurotransmission and is linked to circadian rhythm, emotional and locomotor activity, cognition, memory and learning.
HRH1 mediates smooth muscle contraction and increased capillary permeability through contraction of terminal venules.
As a member of the G protein-coupled receptor 1 family, HRH1 is a model for histamine receptor signalling and comparison with H2, H3 and H4.
HRH1 is a G protein-coupled receptor for histamine. It mediates smooth muscle contraction, increased capillary permeability and catecholamine release from the adrenal medulla. In the central nervous system it mediates neurotransmission, regulating circadian rhythms, emotional and locomotor activities and cognitive functions.
HRH1 is the HGNC symbol for histamine receptor H1, and UniProt names the protein histamine H1 receptor. No alternative symbols are listed. Multiple alternatively spliced transcript variants have been identified, but they all encode the same protein.
Mouse and rat each have an orthologous Hrh1 gene, so rodent studies are common; check the datasheet of any product for its validated reactivity. HRH1 is known to contribute to allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis.
The other histamine receptors, which together mediate the actions of histamine, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35367; product specifications from Assay Genie datasheets.