NFATC1
NFATC1 (nuclear factor of activated T cells 1, also known as NFAT2, NFATc and NF-ATC) is a transcription factor that drives inducible gene expression during the immune response. It also controls gene expression in embryonic cardiac cells and is required for osteoclastogenesis. Browse Assay Genie's current range of NFATC1 research reagents below, or read on for the biology behind the target.
NFATC1 is a component of the nuclear factor of activated T cells (NFAT) DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. The NFATC1 protein is the inducible nuclear component. It plays a role in the inducible expression of cytokine genes in T cells, especially the induction of IL-2 and IL-4 gene transcription.
Beyond cytokine induction, NFATC1 could regulate not only the activation and proliferation but also the differentiation and programmed death of T lymphocytes, as well as lymphoid and non-lymphoid cells. It also controls gene expression in embryonic cardiac cells. NFATC1 is required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. Its subcellular location is both the cytoplasm and the nucleus, consistent with signal-dependent translocation.
The NFATC1 gene produces multiple alternatively spliced transcript variants that encode distinct isoforms, and different isoforms may regulate inducible expression of different cytokine genes. HGNC places the gene in the group of nuclear factors of activated T-cells and the IPT domain containing group. Its previous names include nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. NFATC1 is a major molecular target for immunosuppressive drugs such as cyclosporin A, which makes it a useful subject for studies of immune regulation. The mouse ortholog is Nfatc1.
NFATC1 translocates to the nucleus on TCR stimulation and drives inducible cytokine gene transcription, including IL-2 and IL-4.
NFATC1 is required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
NFATC1 controls gene expression in embryonic cardiac cells, making it relevant to studies of early heart development.
NFATC1 is a major molecular target of immunosuppressive drugs such as cyclosporin A, supporting work on drug mechanism.
NFATC1 is an inducible transcription factor in the NFAT complex. It drives cytokine gene expression in T cells, notably IL-2 and IL-4, controls gene expression in embryonic cardiac cells, and is required for osteoclastogenesis. It may also influence lymphocyte differentiation and programmed death.
NFATC1 is also called NFAT2, NFATc and NF-ATC. Earlier names include nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. Multiple alternatively spliced transcript variants encode distinct isoforms, and different isoforms may regulate different cytokine genes.
A mouse ortholog, Nfatc1, is recorded for the human gene. NFATC1 is a major molecular target for immunosuppressive drugs such as cyclosporin A. Check the datasheet of any product for its validated reactivity.
Other members of the NFAT transcription factor family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95644; product specifications from Assay Genie datasheets.