null

Anti-NFATC1 Antibody (CAB16928)

SKU:
CAB16928
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NFATC1 Antibody
Antibody SKU:CAB16928
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human NFATC1.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:293T, U-87MG, K-562
Immunogen:Recombinant protein of human NFATC1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4772
Uniprot:O95644
Cellular Location:Cytoplasm, Nucleus
Calculated MW:38kDa/74- 88kDa/100-101kDa
Observed MW:75-100kDa
Anti-NFATC1 Antibody (CAB16928)Western blot - NFATC1 Rabbit pAb (CAB16928)
Synonyms:NF-ATC, NF-ATc1.2, NFAT2, NFATc, NFATC1
Background:The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
UniProt Protein Function:NFAT2: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; cytoplasm; cytosol; nucleus

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding; mitogen-activated protein kinase p38 binding; FK506 binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; calcium ion transport; heart development; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; G1/S transition of mitotic cell cycle

NCBI Summary:The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
UniProt Code:O95644
NCBI GenInfo Identifier:8928220
NCBI Gene ID:4772
NCBI Accession:O95644.3
UniProt Secondary Accession:O95644,Q12865, Q15793, Q2M1S3, B5B2M4, B5B2M5, B5B2M6 B5B2M7, B5B2M8, B5B2M9, B5B2N1,
UniProt Related Accession:O95644
Molecular Weight:
NCBI Full Name:Nuclear factor of activated T-cells, cytoplasmic 1
NCBI Synonym Full Names:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NCBI Official Symbol:NFATC1  
NCBI Official Synonym Symbols:NFAT2; NFATc; NF-ATC  
NCBI Protein Information:nuclear factor of activated T-cells, cytoplasmic 1; NFAT transcription complex cytosolic component
UniProt Protein Name:Nuclear factor of activated T-cells, cytoplasmic 1
UniProt Synonym Protein Names:NFAT transcription complex cytosolic component; NF-ATc; NFATc
UniProt Gene Name:NFATC1  
UniProt Entry Name:NFAC1_HUMAN

Related Products