ANP32B
ANP32B (acidic nuclear phosphoprotein 32 family member B, also known as SSP29, PHAPI2 and APRIL) is a member of the ANP32 family of acidic nuclear phosphoproteins. It binds histones and RNA polymerase and is co-opted by several viruses during infection. Browse Assay Genie's current range of ANP32B research reagents below, or read on for the biology behind the target.
ANP32B is an acidic nuclear phosphoprotein belonging to the ANP32 family. According to NCBI Gene, it enables RNA polymerase binding and histone binding activity. It is involved in nucleosome assembly, in the negative regulation of the apoptotic process and in the positive regulation of protein export from the nucleus. Together, these annotations place the ANP32B protein at the interface of chromatin biology, cell survival and nucleocytoplasmic transport.
In microbial infection, UniProt annotates ANP32B as playing an essential role in influenza A and B viral genome replication. It also contributes to the export of foamy virus mRNA from the nucleus to the cytoplasm. This makes it a useful point of study for researchers interested in how viruses exploit host nuclear proteins.
The ANP32B gene is assigned to the HGNC group of ANP32 acidic nuclear phosphoproteins. Its protein is found in the nucleus and cytoplasm, and NCBI Gene reports localisation to the cytosol, nucleolus and nucleoplasm. The official name was previously written as acidic (leucine-rich) nuclear phosphoprotein 32 family, member B. Further aliases include SSP29, PHAPI2 and APRIL. Mouse and rat each have an orthologue named Anp32b, which allows the protein to be studied in common rodent models. Researchers working with ANP32B antibody or ANP32B ELISA kit approaches will often consider its close relative ANP32A, which belongs to the same family.
ANP32B has an essential role in influenza A and B viral genome replication, making it central to host-factor studies of viral polymerase function.
ANP32B contributes to foamy virus mRNA export from the nucleus to the cytoplasm, informing work on viral exploitation of host transport.
ANP32B binds histones and is involved in nucleosome assembly, linking it to research on chromatin organisation.
ANP32B is involved in negative regulation of apoptosis and positive regulation of protein export from the nucleus.
ANP32B binds RNA polymerase and histones, and is involved in nucleosome assembly, negative regulation of apoptosis and positive regulation of protein export from the nucleus. UniProt also annotates an essential role in influenza A and B viral genome replication.
ANP32B is also called SSP29, PHAPI2 and APRIL. Its full name is acidic nuclear phosphoprotein 32 family member B, and UniProt lists it as acidic leucine-rich nuclear phosphoprotein 32 family member B. The earlier HGNC name referred to the 32 family, member B.
Mouse and rat both have an orthologue called Anp32b. ANP32B is one member of the ANP32 family, which also includes ANP32A. Check the datasheet of any product for its validated reactivity.
ANP32A, the closest family member with a live page, and other targets that share similar names or nuclear functions.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92688; product specifications from Assay Genie datasheets.