RCC1
RCC1 (regulator of chromosome condensation 1, also known as CHC1) is a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Through RAN it supports nuclear import and mitosis. Browse Assay Genie's current range of RCC1 research reagents below, or read on for the biology behind the target.
RCC1 is a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP, and so plays an important role in RAN-mediated functions in nuclear import and mitosis. It contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and for normal progress through mitosis.
Because RCC1 maintains high levels of GTP-bound RAN in the nucleus, it also contributes to the release of cargo proteins from importins after nuclear import. The protein binds both nucleosomes and double-stranded DNA, which fits with its association with chromatin. It is also involved in regulating the onset of chromosome condensation in S phase. UniProt lists its subcellular locations as the nucleus, chromosome and cytoplasm.
The human RCC1 gene encodes a protein whose NCBI Gene annotation includes guanyl-nucleotide exchange factor activity, nucleosomal DNA binding and protein heterodimerization activity. It is linked to the G1/S transition of the mitotic cell cycle, regulation of cell cycle processes and spindle organisation, and it is part of a protein-containing complex. The symbol CHC1 and the name chromosome condensation 1 are previous designations for the gene, and the mouse ortholog is Rcc1.
RCC1 maintains GTP-bound RAN in the nucleus, which helps release cargo proteins from importins after nuclear import.
Chromosome-associated GTP-bound RAN generated with RCC1 is important for mitotic spindle assembly and normal progress through mitosis.
RCC1 is involved in the G1/S transition and in the onset of chromosome condensation in S phase.
RCC1 binds nucleosomes and double-stranded DNA, making it a subject for studies of chromatin-associated RAN regulation.
RCC1 is a guanine-nucleotide releasing factor that promotes exchange of Ran-bound GDP for GTP. This maintains high levels of GTP-bound RAN on chromosomes and in the nucleus, supporting nuclear import, mitotic spindle assembly and normal progression through mitosis.
The HGNC name is regulator of chromosome condensation 1. The previous symbol is CHC1, and the previous name is chromosome condensation 1. UniProt lists the protein as Regulator of chromosome condensation. Check the datasheet of any product for its validated reactivity.
UniProt annotates RCC1 in the nucleus, on chromosomes and in the cytoplasm, and NCBI Gene reports it in chromatin, cytoplasm and nuclear lumen. A mouse ortholog, Rcc1, is recorded. Check the datasheet of any product for its validated reactivity.
Ran pathway components, importins and cell cycle regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P18754; product specifications from Assay Genie datasheets.