ADCY1
ADCY1 (adenylate cyclase 1, also known as AC1 and DFNB44) is a membrane-associated enzyme that catalyses the formation of the second messenger cAMP in response to G protein signalling. It is regulated by Ca(2+)/calmodulin and is primarily expressed in the brain. Browse Assay Genie's current range of ADCY1 research reagents below, or read on for the biology behind the target.
ADCY1 catalyses the formation of cyclic AMP (cAMP), a signalling molecule, in response to G protein signalling. It mediates responses to increased cellular Ca(2+)/calmodulin levels, so linking calcium concentration to cAMP production. Its annotated roles include possible involvement in regulatory processes in the central nervous system and a possible role in memory and learning. It is also reported to contribute to the circadian rhythm of daytime contrast sensitivity, probably by modulating the rhythmic synthesis of cAMP in the retina.
The human ADCY1 gene encodes a member of the adenylate cyclase gene family, which belongs to the adenylyl cyclase class-4/guanylyl cyclase family. According to the NCBI Gene summary, the protein is primarily expressed in the brain, is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. In the cell, the ADCY1 protein is annotated to the cell membrane, cytoplasm and membrane rafts.
HGNC places the gene in the adenylate cyclases group. Its approved name was previously written as adenylate cyclase 1 (brain), and the symbol DFNB44 reflects an earlier designation, deafness, autosomal recessive 44. The mouse ortholog is Adcy1. Other family members, such as ADCY2, ADCY5 and ADCY8, also generate cAMP and are useful comparators when studying how different cyclases are regulated.
ADCY1 is primarily expressed in the brain and may be involved in regulatory processes in the central nervous system and in brain development.
UniProt annotates ADCY1 as possibly playing a role in memory and learning, making it a candidate for studying cAMP signalling in cognition.
ADCY1 mediates responses to increased Ca(2+)/calmodulin levels and produces cAMP, linking calcium signals with G protein pathways.
ADCY1 is implicated in the circadian rhythm of daytime contrast sensitivity, probably through rhythmic cAMP synthesis in the retina.
ADCY1 catalyses the formation of the signalling molecule cAMP in response to G protein signalling. It mediates responses to increased Ca(2+)/calmodulin levels and may act in the central nervous system, including memory and learning, and in retinal circadian regulation of contrast sensitivity.
ADCY1 is also known as AC1 and DFNB44, and the protein is named adenylate cyclase type 1. Earlier names include adenylate cyclase 1 (brain) and deafness, autosomal recessive 44. The NCBI Gene summary notes that alternate splicing produces multiple transcript variants.
The mouse counterpart is Adcy1, which allows the gene to be studied in rodent models. ADCY1 belongs to the adenylyl cyclase class-4/guanylyl cyclase family, shared with other adenylate cyclases. Check the datasheet of any product for its validated reactivity.
Other adenylate cyclases and related cAMP-signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08828; product specifications from Assay Genie datasheets.