RAD52
RAD52 (RAD52 DNA repair protein, also known as DNA repair protein RAD52 homolog) is a nuclear protein involved in double-strand break repair. It plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA. Browse Assay Genie's current range of RAD52 research reagents below, or read on for the biology behind the target.
RAD52 is involved in the repair of DNA double-strand breaks. It has a central role in genetic recombination and DNA repair, acting by promoting the annealing of complementary single-stranded DNA and by stimulating the RAD51 recombinase. The protein has been shown to bind single-stranded DNA ends and to mediate the DNA-DNA interaction needed for annealing of complementary strands.
The human RAD52 gene encodes a protein that shares similarity with Saccharomyces cerevisiae Rad52, which is important for double-strand break repair and homologous recombination. The RAD52 protein belongs to the RAD52 family and localises to the nucleus. Its interaction with the DNA recombination protein RAD51 suggests a role in RAD51-related DNA recombination and repair, making it a useful reference point when studying homologous recombination machinery alongside other RAD-family proteins.
Researchers working with the RAD52 gene should be aware that a pseudogene is present on chromosome 2, and that alternative splicing results in multiple transcript variants; further spliced variants have been described whose full-length nature is not known. Previous names reflect the yeast homology, including RAD52 homolog, DNA repair protein and RAD52 (S. cerevisiae) homolog. The mouse ortholog is Rad52, which is relevant for comparative work on recombination and repair.
RAD52 is involved in double-strand break repair, so it is a key protein for studying how cells resolve this form of DNA damage.
RAD52 plays a central role in genetic recombination and interacts with RAD51, supporting studies of RAD51-related recombination pathways.
RAD52 binds single-stranded DNA ends and mediates the DNA-DNA interaction needed for annealing of complementary strands, a mechanism studied in vitro and in cells.
Similarity to yeast Rad52 and a mouse Rad52 ortholog support comparative studies of recombination and repair across species.
RAD52 is involved in double-strand break repair. It plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulating the RAD51 recombinase. It binds single-stranded DNA ends and mediates the DNA-DNA interaction required for annealing.
Previous names include RAD52 homolog, DNA repair protein, and RAD52 (S. cerevisiae) homolog. The official full name is RAD52 DNA repair protein. Alternative splicing produces multiple transcript variants, and additional variants have been described whose full-length nature is not known.
Yes. Human RAD52 shares similarity with Saccharomyces cerevisiae Rad52, a protein important for double-strand break repair and homologous recombination. The mouse ortholog is Rad52. Check the datasheet of any product for its validated reactivity.
Other RAD-family proteins, RAD51 and further DNA repair and recombination factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43351; product specifications from Assay Genie datasheets.