EIF2B5
EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon, also known as EIF2Bepsilon and EIF-2B) is one of five subunits of the eIF2B complex. The complex acts as a guanine nucleotide exchange factor for eIF2 and is an essential regulator of protein synthesis. Browse Assay Genie's current range of EIF2B5 research reagents below, or read on for the biology behind the target.
EIF2B5 is a component of the translation initiation factor 2B (eIF2B) complex, which catalyses the exchange of GDP for GTP on the gamma subunit of eukaryotic initiation factor 2 (eIF2). This exchange recharges eIF2 so that it can deliver methionyl-initiator methionine tRNA to the ribosome. The guanine nucleotide exchange activity of eIF2B is repressed when it is bound to an eIF2 complex that is phosphorylated on its alpha subunit. This limits the methionyl-initiator tRNA available to the ribosome and represses global translation.
The EIF2B5 gene encodes one of the five subunits of eIF2B, a GTP exchange factor for eIF2 and an essential regulator of protein synthesis. The EIF2B5 protein belongs to the eIF-2B gamma/epsilon subunits family and is found in the cytosol. The mouse and rat orthologs are both named Eif2b5.
Mutations in EIF2B5 and in the genes encoding the other eIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. This link makes the subunit relevant to studies of translational control and the regulation of eIF2 activity. Older literature names the gene eukaryotic translation initiation factor 2B, subunit 5 (epsilon, 82kD), and the symbol EIF2Bepsilon is still in use.
EIF2B5 is part of the eIF2B complex, which exchanges GDP for GTP on eIF2 and so regulates protein synthesis.
eIF2B activity is repressed by eIF2 phosphorylated on its alpha subunit, which reduces initiator tRNA delivery and global translation.
Mutations in EIF2B5 and other eIF2B subunit genes are associated with leukoencephalopathy with vanishing white matter.
The eIF2B complex acts as a guanine nucleotide exchange factor for the gamma subunit of eIF2.
EIF2B5 is a subunit of the eIF2B complex, which catalyses the exchange of GDP for GTP on the eIF2 gamma subunit. When eIF2B binds eIF2 phosphorylated on its alpha subunit, its exchange activity is repressed, limiting initiator tRNA availability and reducing global translation.
EIF2B5 is also called EIF2Bepsilon and EIF-2B. Earlier names include eukaryotic translation initiation factor 2B, subunit 5 (epsilon, 82kD). UniProt lists it as translation initiation factor eIF2B subunit epsilon, and it belongs to the eIF-2B gamma/epsilon subunits family.
Mutations in EIF2B5 and the other eIF2B subunit genes are associated with leukoencephalopathy with vanishing white matter. Mouse and rat both have an ortholog named Eif2b5. Check the datasheet of any product for its validated reactivity.
Other eIF2 subunits, eIF2 alpha kinases and translation initiation factors that act alongside eIF2B in protein synthesis control.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13144; product specifications from Assay Genie datasheets.