MYF5
MYF5 (myogenic factor 5, also known as bHLHc2) is a nuclear transcriptional activator that promotes the expression of muscle-specific genes and contributes to muscle differentiation. It belongs to the myogenic regulatory family of basic helix-loop-helix proteins. Browse Assay Genie's current range of MYF5 research reagents below, or read on for the biology behind the target.
MYF5 is a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. It is described as a probable sequence-specific DNA-binding protein. During myogenesis, MYF5 works together with MYOG and MYOD1, which co-occupy the core region of muscle-specific gene promoters. MYF5 can also induce fibroblasts to differentiate into myoblasts, a property that has made it a standard subject in studies of muscle cell identity.
The human MYF5 gene encodes a nuclear protein, and the NCBI Gene summary places it in the nucleoplasm. Its activity is predicted to include DNA-binding transcription factor activity specific to RNA polymerase II, binding to RNA polymerase II cis-regulatory regions, and a contribution to E-box binding. The mouse ortholog is Myf5, which is often used for comparative work on the MYF5 protein.
HGNC classifies MYF5 within the basic helix-loop-helix proteins and the myogenic regulatory family, and lists bHLHc2 as an alias. Predicted biological roles include muscle cell fate commitment, positive regulation of cell differentiation and skeletal muscle cell differentiation. MYF5 is also predicted to act upstream of or within positive regulation of transcription by RNA polymerase II, skeletal system morphogenesis and somitogenesis. Researchers studying the myogenic programme, from fate commitment to differentiation, therefore use MYF5 alongside MYOD1 and MYOG as a reference point.
MYF5 promotes muscle-specific gene transcription and takes part in muscle differentiation, making it central to studies of how muscle tissue forms.
MYF5 is predicted to be involved in muscle cell fate commitment and can induce fibroblasts to differentiate into myoblasts.
MYF5 co-occupies muscle-specific promoter core regions with MYOG and MYOD1, offering a model for cooperative transcription factor binding.
MYF5 is predicted to act upstream of or within somitogenesis and skeletal system morphogenesis, linking it to embryonic patterning.
MYF5 is a transcriptional activator that promotes transcription of muscle-specific target genes and contributes to muscle differentiation. It co-occupies muscle-specific promoter core regions with MYOG and MYOD1 during myogenesis, and it can induce fibroblasts to differentiate into myoblasts.
MYF5 is the HGNC symbol for myogenic factor 5, and bHLHc2 is a listed alias. The name reflects its place among the basic helix-loop-helix proteins, in the myogenic regulatory family, alongside MYOD1 and MYOG.
A mouse ortholog, Myf5, is recognised for the human gene. Cross-species work is therefore possible in mouse models of myogenesis. Check the datasheet of any product for its validated reactivity.
Myogenic regulatory factors that act with MYF5 during muscle differentiation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13349; product specifications from Assay Genie datasheets.