OPTN
OPTN (optineurin, also known as FIP2, HYPL, NRP, HIP7 and GLC1E) is a coiled-coil containing protein linked to glaucoma, innate immune regulation and membrane trafficking. It interacts with several partner proteins, including RAB8, huntingtin and transcription factor IIIA. Browse Assay Genie's current range of OPTN research reagents below, or read on for the biology behind the target.
OPTN encodes optineurin, a coiled-coil containing protein that appears to act through protein-protein interactions. According to RefSeq, it may use tumour necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. It may also contribute to cellular morphogenesis, membrane trafficking, vesicle trafficking and transcription activation through its interactions with RAB8, huntingtin and transcription factor IIIA.
In innate immunity, optineurin is described as a possible cellular target for viruses. Adenovirus E3 14.7 and Bluetongue virus may target it to inhibit the innate immune response, and the OPTN protein interacts with the adenovirus E3-14.7K protein. During RNA virus infection, such as that of Sendai virus, optineurin negatively regulates the induction of IFNB1.
UniProt places optineurin in the cytoplasm, in the perinuclear region, and in the Golgi apparatus and trans-Golgi network. It is also found in autophagosomes, cytoplasmic vesicles and recycling endosomes. This fits with its proposed roles in trafficking. HGNC classifies the OPTN gene in the zinc fingers C2HC NEMO-type group. Alternative splicing produces multiple transcript variants that all encode the same protein.
The gene's previous name, glaucoma 1, open angle, E (adult-onset), and the alias GLC1E reflect its association with disease. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Other aliases include FIP-2 and TFIIIA-INTP, which refer to its interacting partners.
OPTN is linked to normal-tension glaucoma and adult-onset primary open angle glaucoma, so it is a common focus for studies of optic neuropathy.
Optineurin negatively regulates IFNB1 induction during RNA virus infection and may be targeted by viruses to dampen innate immune responses.
Optineurin interacts with RAB8 and localises to the Golgi, vesicles and recycling endosomes, which makes it relevant to trafficking studies.
Optineurin is found in autophagosomes and may mediate apoptosis and inflammation through tumour necrosis factor-alpha or Fas-ligand pathways.
Optineurin is a coiled-coil protein that may mediate apoptosis, inflammation or vasoconstriction through tumour necrosis factor-alpha or Fas-ligand pathways. It may also function in membrane and vesicle trafficking. During RNA virus infection it negatively regulates the induction of IFNB1.
Aliases include FIP2, FIP-2, HYPL, TFIIIA-INTP, NRP, HIP7 and GLC1E. The previous HGNC name was glaucoma 1, open angle, E (adult-onset). Alternative splicing yields multiple transcript variants, but all encode the same protein.
Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Mouse and rat each have an ortholog named Optn. Check the datasheet of any product for its validated reactivity.
Other trafficking, innate immunity and glaucoma-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96CV9; product specifications from Assay Genie datasheets.