Adenosine A2A Receptor
Adenosine A2A Receptor (ADORA2A, also known as RDC8 and ADORA2) is a cell-membrane G protein-coupled receptor for adenosine. Its signalling is mediated by G proteins that activate adenylyl cyclase, raising intracellular cAMP. Browse Assay Genie's current range of Adenosine A2A Receptor research reagents below, or read on for the biology behind the target.
Adenosine A2A Receptor is a receptor for adenosine. Its activity is mediated by G proteins that activate adenylyl cyclase. It uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) families of G proteins to increase intracellular cAMP levels. In this way it converts an extracellular cue into an intracellular signal transduction response.
The ADORA2A gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. UniProt places the protein in the G protein-coupled receptor 1 family, and HGNC classifies it within the adenosine receptors gene group. Like other members of the superfamily, it is a seven-pass transmembrane protein located at the cell membrane. Alternative splicing of the gene produces multiple transcript variants. A read-through transcript combining the upstream SPECC1L gene with ADORA2A has also been identified, but it is thought to be non-coding. Mouse and rat both carry an orthologous Adora2a gene.
The receptor plays an important role in many biological functions, including cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders, which is why the A2A subtype is studied in both immunology and neuroscience. Other adenosine receptor subtypes, including A1, A2B and A3, form the wider family in which A2A signalling is usually considered.
A Gs/Golf-coupled receptor that activates adenylyl cyclase and raises cAMP, making it a model for studying adenosine-driven signal transduction.
The receptor has been implicated in neurodegenerative disorders and contributes to sleep regulation and pain control.
It contributes to immune function and has been implicated in inflammatory diseases, so it is studied in immune regulation.
The receptor influences cardiac rhythm and circulation, as well as cerebral and renal blood flow.
It is a receptor for adenosine. On binding adenosine it couples mainly to G(s) and G(olf) proteins, which activate adenylyl cyclase and increase intracellular cAMP. This signalling contributes to cardiac rhythm, blood flow, immune function, pain regulation and sleep.
The gene symbol is ADORA2A, with RDC8 and ADORA2 as aliases. HGNC gives the full name as adenosine A2a receptor, and UniProt calls the protein adenosine receptor A2a. Alternative splicing gives multiple transcript variants, and a SPECC1L read-through transcript is thought to be non-coding.
Mouse and rat both have an orthologous Adora2a gene; check the datasheet of any product for its validated reactivity. The human receptor has been implicated in inflammatory diseases and neurodegenerative disorders.
Other adenosine receptor subtypes that share the adenosine-responsive GPCR family with Adenosine A2A Receptor.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P29274; product specifications from Assay Genie datasheets.