CSDE1
CSDE1 (cold shock domain containing E1) is a cytoplasmic RNA-binding protein of the UNR family, also known as UNR or D1S155E. It binds RNA stem-loops and contributes to translational control, mRNA stability and stress granule assembly. Browse Assay Genie's current range of CSDE1 research reagents below, or read on for the biology behind the target.
CSDE1 is an RNA-binding protein that acts in post-transcriptional regulation of gene expression. According to NCBI Gene, it enables RISC complex binding, RNA stem-loop binding and lncRNA binding activity, and it forms part of the CRD-mediated mRNA stability complex. It is also involved in stress granule assembly. UniProt annotates a role in infection: the protein is required for internal initiation of translation of human rhinovirus RNA, and NCBI links it to IRES-dependent viral translational initiation.
The CSDE1 protein is located in the cytosol. UniProt records its subcellular locations as the cytoplasm, including stress granules and P-bodies, which are both sites of mRNA regulation and storage. These locations fit its involvement in stress responses and in the control of mRNA fate. Researchers studying RNA-binding proteins, translational control or ribonucleoprotein granules commonly use CSDE1 antibody and CSDE1 ELISA kit approaches to follow its abundance and localisation.
The CSDE1 gene belongs to the HGNC gene group of cold shock domain containing proteins, and the protein is assigned to the UNR family. The name UNR is a widely used alias, and D1S155E is a previous symbol. The HGNC previous name, cold shock domain containing E1, RNA binding, reflects its function. Mouse and rat both have a Csde1 ortholog.
CSDE1 is involved in IRES-dependent translational initiation and regulation of gene expression, making it a useful subject for studies of how mRNAs are selected for translation.
CSDE1 is involved in stress granule assembly and localises to stress granules and P-bodies, supporting work on cytoplasmic RNA granules.
As part of the CRD-mediated mRNA stability complex, CSDE1 is relevant to research on how RNA-binding proteins determine transcript lifetime.
UniProt reports that CSDE1 is required for internal initiation of translation of human rhinovirus RNA, linking it to host factor studies in viral infection.
CSDE1 is an RNA-binding protein. It binds RNA stem-loops and lncRNA, binds the RISC complex, and is part of the CRD-mediated mRNA stability complex. It is involved in regulating gene expression and in stress granule assembly, and it is required for rhinovirus RNA translation.
CSDE1 is also called UNR, and D1S155E is a previous symbol. The full name is cold shock domain containing E1, and UniProt lists it as cold shock domain-containing protein E1. HGNC also records the earlier name cold shock domain containing E1, RNA binding.
Yes. Mouse and rat each have an ortholog named Csde1, which allows the protein to be studied in rodent models. Researchers should check the datasheet of any product for its validated reactivity.
Other RNA-binding proteins and stress granule components that may be of interest alongside CSDE1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75534; product specifications from Assay Genie datasheets.