KRT17
KRT17 (keratin 17, also known as PCHC1) is a type I intermediate filament protein and a structural component of epithelial keratinocytes. It contributes to nail, hair follicle and other epidermal appendage biology, and also influences epithelial growth and skin immune responses. Browse Assay Genie's current range of KRT17 research reagents below, or read on for the biology behind the target.
KRT17 is a structural component of intermediate filaments in epithelial keratinocytes. It forms heteropolymers with the type II keratins KRT6A and KRT6B, and these assemble into keratin filament networks that support the structural integrity and specialised differentiation of epithelial appendages, including the nail and the hair follicle. KRT17 is required for correct hair follicle growth, in particular for persistence of the anagen (growth) state, and it modulates the function of TNF in the specific context of hair cycling.
Beyond its structural role, KRT17 regulates protein synthesis and epithelial cell growth. It does so by binding the adapter protein SFN and by stimulating the Akt/mTOR pathway. It is also involved in tissue repair. In skin, KRT17 acts as a regulator of the immune response: it promotes a Th1/Th17-dominated immune environment, which contributes to the development of basaloid skin tumours, and it promotes epithelial proliferation. It may also act as an autoantigen in the immunopathogenesis of psoriasis, where certain peptide regions are a major target for autoreactive T-cells and cause their proliferation.
The KRT17 gene encodes the type I intermediate filament chain keratin 17, which belongs to the intermediate filament family and to the HGNC group of type I keratins. It is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Mutations in the gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. The previous gene name was keratin 17, type I, and the symbol PCHC1 is a recorded alias.
KRT17 is required for correct hair follicle growth and for persistence of the anagen state, and it modulates TNF function in hair cycling.
KRT17 may act as an autoantigen in psoriasis, with peptide regions targeted by autoreactive T-cells, and it promotes a Th1/Th17-dominated skin environment.
KRT17 binds SFN and stimulates the Akt/mTOR pathway, regulating protein synthesis and epithelial cell growth.
Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex, making it relevant to keratin disease studies.
KRT17 is a structural component of intermediate filaments in epithelial keratinocytes. It pairs with KRT6A and KRT6B to form keratin networks in nail and hair follicle, supports hair follicle growth, contributes to tissue repair, and regulates epithelial growth through SFN binding and Akt/mTOR signalling.
The HGNC name is keratin 17, with the previous name keratin 17, type I, and the alias PCHC1. UniProt lists the protein as Keratin, type I cytoskeletal 17. It belongs to the type I keratins within the intermediate filament family.
Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex, and it may be an autoantigen in psoriasis. Mouse and rat both have a Krt17 ortholog; check the datasheet of any product for its validated reactivity.
Other keratins, including the type II partner KRT6A and further type I and type II family members, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q04695; product specifications from Assay Genie datasheets.